Slc5a8 blocking peptide

Mouse Slc5a8 Blocking Peptide (C-term)

• Gene Names: Slc5a8; Ait; SMCT
• Synonyms: Slc5a8; Mouse Slc5a8 Blocking Peptide (C-term); Sodium-coupled monocarboxylate transporter 1; Electrogenic sodium monocarboxylate cotransporter; Solute carrier family 5 member 8; Slc5a8 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 563-574 of MOUSE Slc5a8
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 611

• Cellular Location: Membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein Note: Restricted to the apical cell membrane of enterocytes
• Tissue Location: Expressed in brain, colon, kidney and in the ileum and jejunum of small intestine. In the kidney, expression occurred in the proximal tubule and the loop of Henle, being restricted to tubular epithelial cells in both the cortex and the medulla. In the colon, predominantly expressed in the distal half of the large bowel and in the most terminal ileum. Localized selectively in the luminal surface of crypts in the large intestine and to the brush border in the middle parts of crypts in the cecum. In the brain, expression was seen throughout, exclusively in neurons, including the cortex, hippocampus, cerebellum and pituitary gland (at protein level). Expression is reduced in oligodendrogliomas.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Slc5a8 blocking peptide

Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

NCBI and Uniprot Product Information

• NCBI GI #: 110347555
• NCBI GeneID: 216225
• NCBI Accession #: NP_663398.2
• NCBI GenBank Nucleotide #: NM_145423.2
• UniProt Accession #: Q8BYF6; Q8VD01
• Molecular Weight: 66,766 Da
• NCBI Official Full Name: sodium-coupled monocarboxylate transporter 1
• NCBI Official Synonym Full Names: solute carrier family 5 (iodide transporter), member 8
• NCBI Official Symbol: Slc5a8
• NCBI Official Synonym Symbols: Ait; SMCT
• NCBI Protein Information: sodium-coupled monocarboxylate transporter 1
• UniProt Protein Name: Sodium-coupled monocarboxylate transporter 1
• Protein Family: Sodium-coupled monocarboxylate transporter
• UniProt Gene Name: Slc5a8
• UniProt Entry Name: SC5A8_MOUSE

Uniprot Description

SLC5A8: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Apoptosis; Tumor suppressor; Transporter

Cellular Component: integral to plasma membrane

Molecular Function: symporter activity