SLC5A12 blocking peptide

SLC5A12 Antibody (C-term) Blocking peptide

• Gene Names: SLC5A12; SMCT2
• Synonyms: SLC5A12; SLC5A12 Antibody (C-term) Blocking peptide; Sodium-coupled monocarboxylate transporter 2; Electroneutral sodium monocarboxylate cotransporter; Low-affinity sodium-lactate cotransporter; Solute carrier family 5 member 12; SMCT2; SLC5A12 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 618

• Cellular Location: Apical cell membrane; Multi-pass membrane protein. Note: Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SLC5A12 blocking peptide

Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 157671931
• NCBI GeneID: 159963
• NCBI Accession #: NP_848593.2
• NCBI GenBank Nucleotide #: NM_178498.3
• UniProt Accession #: Q1EHB4; Q86UC7
• Molecular Weight: 44,077 Da
• NCBI Official Full Name: sodium-coupled monocarboxylate transporter 2
• NCBI Official Synonym Full Names: solute carrier family 5 member 12
• NCBI Official Symbol: SLC5A12
• NCBI Official Synonym Symbols: SMCT2
• NCBI Protein Information: sodium-coupled monocarboxylate transporter 2
• UniProt Protein Name: Sodium-coupled monocarboxylate transporter 2
• Protein Family: Sodium-coupled monocarboxylate transporter
• UniProt Gene Name: SLC5A12
• UniProt Synonym Gene Names: SMCT2
• UniProt Entry Name: SC5AC_HUMAN

NCBI Description

Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]).[supplied by OMIM, Dec 2008]

Uniprot Description

SLC5A12: Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p14.2

Cellular Component: integral to plasma membrane

Molecular Function: lactate transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity; symporter activity