SLC40A1 blocking peptide

SLC40A1 Blocking Peptide

Gene Names

SLC40A1; FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3

Applications

Blocking/Control

Purity

The purity is >90%,tested by HPLC and MS.

Synonyms

SLC40A1; SLC40A1 Blocking Peptide; Ferroportin 1; Ferroportin; Ferroportin-1; FPN1; HFE4; IREG1; iron regulated gene 1; Iron regulated transporter 1; Iron-regulated transporter 1; MST079; MSTP079; MTP1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; S40A1_HUMAN; SLC11A3; formerly; solute carrier family 11 (proton-coupled divalent metal ion transporters); member 3; solute carrier family 40 (iron-regulated transporter); member 1; Solute carrier family 40 member 1; SLC40A1 blocking peptide

Ordering
Cat. Num. AAA9622264 For Research Use Only!

Purity/Purification

The purity is >90%,tested by HPLC and MS.

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

Applicable Applications for SLC40A1 blocking peptide

Blocking/Control

Notes

For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SLC40A1 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

NCBI GI #

67633296

NCBI GeneID

30061

UniProt Accession #

Q9NP59; Q6FI62; Q7Z4F8; Q8IVB2; Q9NRL0

Molecular Weight

62,542 Da

NCBI Official Full Name

ferroportin 1 variant I, partial

NCBI Official Synonym Full Names

solute carrier family 40 (iron-regulated transporter), member 1

NCBI Official Symbol

SLC40A1

NCBI Official Synonym Symbols

FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3

NCBI Protein Information

solute carrier family 40 member 1; iron regulated gene 1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3

UniProt Protein Name

Solute carrier family 40 member 1

UniProt Gene Name

SLC40A1

UniProt Synonym Gene Names

FPN1; IREG1; SLC11A3

UniProt Entry Name

S40A1_HUMAN

NCBI Description

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

Uniprot Description

SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: multivesicular body; synaptic vesicle; integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; integral to membrane; intracellular

Molecular Function: protein binding; iron ion transmembrane transporter activity

Biological Process: anatomical structure morphogenesis; cellular iron ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; transmembrane transport; lymphocyte homeostasis; negative regulation of apoptosis

Disease: Hemochromatosis, Type 4

Research Articles on SLC40A1

1. Manganese (Mn) transport carriers DMT1 and FPN1 mediate the apical uptake and basolateral exit of Mn in colonic epithelial Caco-2 cells.

Similar Products

FPN ELISA Kit

Host: n/a

Reactivity: Rabbit

Apps: n/a

Product Notes

The SLC40A1 slc40a1 (Catalog #AAA9622264) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's SLC40A1 can be used in a range of immunoassay formats including, but not limited to, Blocking/Control. Researchers should empirically determine the suitability of the SLC40A1 slc40a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC40A1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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SLC40A1 blocking peptide