SLC2A4 blocking peptide

SLC2A4 Blocking Peptide (C-term)

• Gene Names: SLC2A4; GLUT4
• Synonyms: SLC2A4; SLC2A4 Blocking Peptide (C-term); Solute carrier family 2; facilitated glucose transporter member 4; Glucose transporter type 4; insulin-responsive; GLUT-4; GLUT4; SLC2A4 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 495-509 of HUMAN SLC2A4
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 509

• Cellular Location: Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note: Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration
• Tissue Location: Skeletal and cardiac muscles; brown and white fat
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SLC2A4 blocking peptide

Insulin-regulated facilitative glucose transporter.

NCBI and Uniprot Product Information

• NCBI GI #: 121761
• NCBI GeneID: 6517
• UniProt Accession #: P14672; Q05BQ3; Q14CX2
• Molecular Weight: 43,760 Da
• NCBI Official Full Name: Solute carrier family 2, facilitated glucose transporter member 4
• NCBI Official Synonym Full Names: solute carrier family 2 member 4
• NCBI Official Symbol: SLC2A4
• NCBI Official Synonym Symbols: GLUT4
• NCBI Protein Information: solute carrier family 2, facilitated glucose transporter member 4
• UniProt Protein Name: Solute carrier family 2, facilitated glucose transporter member 4
• Protein Family: SLC2A4 regulator
• UniProt Gene Name: SLC2A4
• UniProt Synonym Gene Names: GLUT4; GLUT-4
• UniProt Entry Name: GTR4_HUMAN

NCBI Description

This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]

Uniprot Description

GLUT4: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Its surface expression is regulated by insulin. Has two internalization sequences, a dileucine repeat present in the C-terminus and a FxxY motif in the amino-terminal end. Associates with an intracellular tubulo-vesicular compartment under low plasma conditions. The binding of insulin to the insulin receptor (a typosine kinase) leads to the rapid translocation of GLUT4 to the cell surface, increasing cellular glucose transport activity. Its translocation to the plasma membrane is also stimulated by exercise, but independent from insulin signaling. This insulin-independent pathway may be regulated by AMPK.

Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: clathrin-coated vesicle; endomembrane system; external side of plasma membrane; membrane; perinuclear region of cytoplasm; plasma membrane; vesicle membrane

Molecular Function: D-glucose transmembrane transporter activity; glucose transmembrane transporter activity; protein binding

Biological Process: carbohydrate metabolic process; cellular response to insulin stimulus; glucose homeostasis; glucose transport

Disease: Diabetes Mellitus, Noninsulin-dependent