SLC29A1 blocking peptide

SLC29A1 Peptide

Cat. Num. AAA153907

• Gene Names: SLC29A1; ENT1
• Applications: Blocking (BL)
• Synonyms: SLC29A1; SLC29A1 Peptide; Solute carrier family 29 member 1; Equilibrative nucleoside transporter 1; ENT1; solute carrier family 29 (equilibrative nucleoside transporter); member 1; SLC29A1 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 535

• Applicable Applications for SLC29A1 blocking peptide: Blocking (BL)
• Application Notes: SLC29A1 peptide is used for blocking the activity of SLC29A1 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 17 amino acid peptide near the center of human SLC29A1.
• Preparation and Storage: Store SLC29A1 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 4826716
• NCBI GeneID: 2030
• NCBI Accession #: NP_004946
• NCBI GenBank Nucleotide #: NM_004955.2
• UniProt Accession #: Q99808; Q5T9W9; Q9UJY2; B3KQV7; B3KQY5
• Molecular Weight: 58,963 Da
• NCBI Official Synonym Full Names: solute carrier family 29 (equilibrative nucleoside transporter), member 1
• NCBI Official Symbol: SLC29A1
• NCBI Official Synonym Symbols: ENT1
• NCBI Protein Information: equilibrative nucleoside transporter 1
• UniProt Protein Name: Equilibrative nucleoside transporter 1
• Protein Family: Equilibrative nucleoside transporter
• UniProt Gene Name: SLC29A1
• UniProt Synonym Gene Names: ENT1; Equilibrative NBMPR-sensitive nucleoside transporter
• UniProt Entry Name: S29A1_HUMAN

NCBI Description

This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SLC29A1: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs). Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.

Protein type: Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: membrane; basolateral plasma membrane; integral to plasma membrane; apical plasma membrane; plasma membrane

Molecular Function: nucleoside transmembrane transporter activity

Biological Process: lactation; nucleoside transport; uridine transport; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; regulation of excitatory postsynaptic membrane potential; sleep; transmembrane transport