SHQ1 blocking peptide

SHQ1 Antibody (N-term) Blocking peptide

• Gene Names: SHQ1; Shq1p; GRIM-1
• Synonyms: SHQ1; SHQ1 Antibody (N-term) Blocking peptide; Protein SHQ1 homolog; SHQ1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 577

• Cellular Location: Cytoplasm, cytosol. Nucleus, nucleoplasm. Note: May at least partially shuttle between cytosol and nucleoplasm. In the nucleoplasm, exhibits a granular pattern, but is excluded from nucleoli and Cajal bodies Absent from most H/ACA-box RNA transcription sites
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SHQ1 blocking peptide

Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.

NCBI and Uniprot Product Information

• NCBI GI #: 158563966
• NCBI GeneID: 55164
• UniProt Accession #: Q6PI26; Q6MZJ4; Q7Z748; Q9H7E5; Q9NVS8; B4DL05
• Molecular Weight: 61,548 Da
• NCBI Official Full Name: Protein SHQ1 homolog
• NCBI Official Synonym Full Names: SHQ1, H/ACA ribonucleoprotein assembly factor
• NCBI Official Symbol: SHQ1
• NCBI Official Synonym Symbols: Shq1p; GRIM-1
• NCBI Protein Information: protein SHQ1 homolog
• UniProt Protein Name: Protein SHQ1 homolog
• Protein Family: Protein
• UniProt Gene Name: SHQ1
• UniProt Entry Name: SHQ1_HUMAN

NCBI Description

SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs, modification of spliceosomal small nuclear RNAs, and stabilization of telomerase (see MIM 602322) (Grozdanov et al., 2009 [PubMed 19383767]).[supplied by OMIM, Dec 2010]

Uniprot Description

SHQ1: Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. Belongs to the SHQ1 family.

Chromosomal Location of Human Ortholog: 3p13

Cellular Component: Cajal body; cytoplasm; nucleolus; nucleoplasm

Molecular Function: protein binding

Biological Process: positive regulation of apoptosis; protein-RNA complex assembly