SHOC2 blocking peptide

SHOC2 Peptide

Cat. Num. AAA152794

• Gene Names: SHOC2; SOC2; SUR8; SIAA0862
• Applications: Blocking (BL)
• Synonyms: SHOC2; SHOC2 Peptide; SOC2; SUR8; SIAA0862; KIAA0862; Leucine-rich repeat protein SHOC-2; Protein soc-2 homolog; soc-2 suppressor of clear homolog (C. elegans); SHOC2 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 582

• Applicable Applications for SHOC2 blocking peptide: Blocking (BL)
• Application Notes: SHOC2 peptide is used for blocking the activity of SHOC2 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 21 amino acids near the amino terminus of human SHOC2.
• Preparation and Storage: Store SHOC2 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 41281398
• NCBI GeneID: 8036
• NCBI Accession #: NP_031399
• NCBI GenBank Nucleotide #: NM_007373.3
• UniProt Accession #: Q9UQ13; O76063; Q5VZS8; Q5VZS9; A8K9W8; B3KR23
• Molecular Weight: 59,743 Da
• NCBI Official Full Name: leucine-rich repeat protein SHOC-2 isoform 1
• NCBI Official Synonym Full Names: soc-2 suppressor of clear homolog (C. elegans)
• NCBI Official Symbol: SHOC2
• NCBI Official Synonym Symbols: SOC2; SUR8; SIAA0862
• NCBI Protein Information: leucine-rich repeat protein SHOC-2
• UniProt Protein Name: Leucine-rich repeat protein SHOC-2
• Protein Family: Leucine-rich repeat protein
• UniProt Gene Name: SHOC2
• UniProt Synonym Gene Names: KIAA0862
• UniProt Entry Name: SHOC2_HUMAN

NCBI Description

This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]

Uniprot Description

SHOC2: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. Defects in SHOC2 are the cause of Noonan syndrome-like disorder with loose anagen hair (NSLH). A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair. Belongs to the SHOC2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 10q25

Cellular Component: nucleoplasm; cytoplasm; protein phosphatase type 1 complex; nucleus

Molecular Function: protein phosphatase regulator activity; protein phosphatase binding

Biological Process: fibroblast growth factor receptor signaling pathway; regulation of catalytic activity; Ras protein signal transduction; positive regulation of Ras protein signal transduction

Disease: Noonan Syndrome-like Disorder With Loose Anagen Hair