Shc4 blocking peptide
Mouse Shc4 Antibody(C-term) Blocking peptide
Gene Names
Shc4; RaLP; Gm685; 6230417E10Rik; 9930029B02Rik
Synonyms
Shc4; Mouse Shc4 Antibody(C-term) Blocking peptide; SHC-transforming protein 4; Rai-like protein; RaLP; SHC-transforming protein D; mShcD; Src homology 2 domain-containing-transforming protein C4; SH2 domain protein C4; Shcd; Shc4 blocking peptide
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
626
Cellular Location
Cell junction, synapse, postsynaptic cell membrane. Note: Colocalized with MUSK at the neuromuscular junction
Tissue Location
Expressed in both brain and skeletal muscle; widely expressed in brain namely olfactory bulb, cortex, hippocampus, striatum, thalamus, and brain stem (at protein level). Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for Shc4 blocking peptide
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
68,519 Da
NCBI Official Full Name
SHC-transforming protein 4
NCBI Official Synonym Full Names
SHC (Src homology 2 domain containing) family, member 4
NCBI Official Symbol
Shc4
NCBI Official Synonym Symbols
RaLP; Gm685; 6230417E10Rik; 9930029B02Rik
NCBI Protein Information
SHC-transforming protein 4
UniProt Protein Name
SHC-transforming protein 4
Protein Family
UniProt Gene Name
Shc4
UniProt Synonym Gene Names
Shcd; RaLP; mShcD; SH2 domain protein C4
UniProt Entry Name
SHC4_MOUSE
Uniprot Description
SHC4: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Cellular Component: plasma membrane
Molecular Function: protein domain specific binding; receptor tyrosine kinase binding
Biological Process: apoptosis; positive regulation of cell proliferation; regulation of gene expression; stem cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on Shc4
Similar Products
Product Notes
The Shc4 shc4 (Catalog #AAA9224433) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Shc4, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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