SCN7A blocking peptide

SCN7A Blocking Peptide

Cat. Num. AAA9619618

• Gene Names: SCN7A; NaG; SCN6A; Nav2.1; Nav2.2
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: SCN7A; SCN7A Blocking Peptide; Putative voltage gated sodium channel subunit alpha Nax; SCN 6A; SCN 7A; SCN6A; Sodium channel protein cardiac and skeletal muscle subunit alpha; Sodium channel protein type 7 subunit alpha; Sodium channel protein type VII subunit alpha; Sodium channel voltage gated type VI alpha polypeptide; Sodium channel voltage gated type VII alpha; Sodium channel voltage gated type VII alpha polypeptide; Voltage dependent sodium channel alpha subunit; SCN7A blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for SCN7A blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SCN7A blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 111378393
• NCBI GeneID: 6332
• NCBI Accession #: NP_002967.2
• NCBI GenBank Nucleotide #: NM_002976.3
• UniProt Accession #: Q01118
• Molecular Weight: 193,493 Da
• NCBI Official Full Name: sodium channel protein type 7 subunit alpha
• NCBI Official Synonym Full Names: sodium channel, voltage-gated, type VII, alpha subunit
• NCBI Official Symbol: SCN7A
• NCBI Official Synonym Symbols: NaG; SCN6A; Nav2.1; Nav2.2
• NCBI Protein Information: sodium channel protein type 7 subunit alpha; sodium channel protein type VII subunit alpha; voltage-dependent sodium channel alpha subunit; putative voltage-gated sodium channel subunit alpha Nax; sodium channel, voltage-gated, type VI, alpha polypeptide
• UniProt Protein Name: Sodium channel protein type 7 subunit alpha
• Protein Family: Sodium channel protein
• UniProt Gene Name: SCN7A
• UniProt Synonym Gene Names: SCN6A
• UniProt Entry Name: SCN7A_HUMAN

NCBI Description

This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011]

Uniprot Description

SCN7A: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Belongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily.

Protein type: Membrane protein, multi-pass; Channel, sodium; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q21-q23

Cellular Component: voltage-gated sodium channel complex; plasma membrane

Molecular Function: voltage-gated sodium channel activity

Biological Process: muscle contraction; sodium ion transport; generation of action potential; sodium ion homeostasis