Rabbit anti-Human, Mouse SCN7A Polyclonal Antibody | anti-SCN7A antibody

Anti-SCN7A Antibody

Cat. Num. AAA8308037

• Gene Names: SCN7A; NaG; SCN6A; Nav2.1; Nav2.2
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Immunogen Affinity Chromatography
• Synonyms: SCN7A; Polyclonal Antibody; Anti-SCN7A Antibody; SCN6A; Sodium channel protein type 7 subunit alpha; Putative voltage-gated sodium channel subunit alpha Nax; Sodium channel protein cardiac and skeletal muscle subunit alpha; Sodium channel protein type VII subunit alpha; anti-SCN7A antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of SCN7A protein.
• Purity/Purification: Purified by Immunogen Affinity Chromatography
• Form/Format: Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

• Applicable Applications for anti-SCN7A antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant fusion protein of human SCN7A. The exact sequence is proprietary.
• Preparation and Storage: Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of SCN7A expression in HeLa (A), mouse heart (B) whole cell lysates.)

Related Product Information for anti-SCN7A antibody

Rabbit polyclonal antibody to SCN7A

NCBI and Uniprot Product Information

• NCBI GI #: 111378393
• NCBI GeneID: 6332
• NCBI Accession #: NP_002967.2
• NCBI GenBank Nucleotide #: NM_002976.3
• UniProt Accession #: Q01118
• Molecular Weight: 193,493 Da
• NCBI Official Full Name: sodium channel protein type 7 subunit alpha
• NCBI Official Synonym Full Names: sodium channel, voltage-gated, type VII, alpha subunit
• NCBI Official Symbol: SCN7A
• NCBI Official Synonym Symbols: NaG; SCN6A; Nav2.1; Nav2.2
• NCBI Protein Information: sodium channel protein type 7 subunit alpha; sodium channel protein type VII subunit alpha; voltage-dependent sodium channel alpha subunit; putative voltage-gated sodium channel subunit alpha Nax; sodium channel, voltage-gated, type VI, alpha polypeptide
• UniProt Protein Name: Sodium channel protein type 7 subunit alpha
• Protein Family: Sodium channel protein
• UniProt Gene Name: SCN7A
• UniProt Synonym Gene Names: SCN6A
• UniProt Entry Name: SCN7A_HUMAN

NCBI Description

This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011]

Uniprot Description

SCN7A: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Belongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily.

Protein type: Membrane protein, multi-pass; Channel, sodium; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q21-q23

Cellular Component: voltage-gated sodium channel complex; plasma membrane

Molecular Function: voltage-gated sodium channel activity

Biological Process: muscle contraction; sodium ion transport; generation of action potential; sodium ion homeostasis