SAFB blocking peptide

SAFB Antibody (N-term) Blocking Peptide

• Gene Names: SAFB; HAP; HET; SAF-B; SAFB1; SAB-B1; SAF-B1
• Synonyms: SAFB; SAFB Antibody (N-term) Blocking Peptide; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein; HAP; HET; SAFB1; SAFB blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 915

• Cellular Location: Nucleus.
• Tissue Location: Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SAFB blocking peptide

Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Can inhibit cell proliferation.

NCBI and Uniprot Product Information

• NCBI GI #: 116242782
• NCBI GeneID: 6294
• UniProt Accession #: Q15424; O60406; Q59HH8; A0AV56; B7Z5B6; B7ZLP6; F5H0H3
• Molecular Weight: 102,768 Da
• NCBI Official Full Name: Scaffold attachment factor B1
• NCBI Official Synonym Full Names: scaffold attachment factor B
• NCBI Official Symbol: SAFB
• NCBI Official Synonym Symbols: HAP; HET; SAF-B; SAFB1; SAB-B1; SAF-B1
• NCBI Protein Information: scaffold attachment factor B1
• UniProt Protein Name: Scaffold attachment factor B1
• Protein Family: Scaffold attachment factor
• UniProt Gene Name: SAFB
• UniProt Synonym Gene Names: HAP; HET; SAFB1; SAF-B; SAF-B1; HSP27 ERE-TATA-binding protein
• UniProt Entry Name: SAFB1_HUMAN

NCBI Description

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

Uniprot Description

SAFB1: Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter. Can inhibit cell proliferation.

Protein type: RNA-binding; DNA-binding; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: double-stranded DNA binding; protein binding

Biological Process: establishment and/or maintenance of chromatin architecture