ROS1 blocking peptide

ROS1 Blocking Peptide (C-term)

• Gene Names: ROS1; ROS; MCF3; c-ros-1
• Synonyms: ROS1; ROS1 Blocking Peptide (C-term); Proto-oncogene tyrosine-protein kinase ROS; Proto-oncogene c-Ros; Proto-oncogene c-Ros-1; Receptor tyrosine kinase c-ros oncogene 1; c-Ros receptor tyrosine kinase; MCF3; ROS; ROS1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 1744-1757 of HUMAN ROS1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 2347

• Cellular Location: Cell membrane; Single-pass type I membrane protein
• Tissue Location: Expressed in brain. Expression is increased in primary gliomas.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ROS1 blocking peptide

Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

NCBI and Uniprot Product Information

• NCBI GI #: 126302596
• NCBI GeneID: 6098
• UniProt Accession #: P08922; Q15368; Q5TDB5
• Molecular Weight: 263,915 Da
• NCBI Official Full Name: Proto-oncogene tyrosine-protein kinase ROS
• NCBI Official Synonym Full Names: ROS proto-oncogene 1, receptor tyrosine kinase
• NCBI Official Symbol: ROS1
• NCBI Official Synonym Symbols: ROS; MCF3; c-ros-1
• NCBI Protein Information: proto-oncogene tyrosine-protein kinase ROS
• UniProt Protein Name: Proto-oncogene tyrosine-protein kinase ROS
• Protein Family: Protein
• UniProt Gene Name: ROS1
• UniProt Synonym Gene Names: MCF3; ROS
• UniProt Entry Name: ROS1_HUMAN

NCBI Description

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]

Uniprot Description

ROS: a proto-oncogenic receptor tyrosine kinase whose expression is tightly restricted during development. Normally expressed in adult murine and human epithelial cells of the epididymis. Transgenic mice lacking the c-ros gene are infertile. Ectopic expression of c-Ros has been reported in meningiomas and astrocytomas. Is up-regulated in human glioma: 30% of malignant glioma tumors are ROS positive. An oncogenic fusion protein between PIST (aka FIG) and ROS, resulting from an intra-chromosomal homozygous deletion of 240 kilobases on 6q21, is found in glioblastoma multiform. PIST (aka FIG) is a peripheral membrane protein associated with the Golgi apparatus. Unlike other fusion RTK oncogenes, the mechanism of activation of PIST-ROS does not appear to be dimerization: the PIST-ROS fusion protein appears to be monomeric in vivo. Rather, activation of the fused ROS kinase appears to depend upon translocation to the golgi apparatus: deletion of 2nd coiled-coil region of PIST, crucial for Golgi localization, appears to eliminate the transformation capacity of PIST-ROS. c-ROS may also be activated epigenetically, suggesting caution when using 5-aza-dC for treating glioma.

Protein type: EC 2.7.10.1; Kinase, protein; Oncoprotein; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Sev family

Chromosomal Location of Human Ortholog: 6q22

Cellular Component: membrane

Molecular Function: protein binding; protein phosphatase binding; protein-tyrosine kinase activity

Biological Process: cell differentiation; cell growth; cell proliferation; columnar/cuboidal epithelial cell development; protein amino acid phosphorylation; regulation of TOR signaling pathway; spermatogenesis