RGS1 blocking peptide

RGS1 Antibody (N-term) Blocking Peptide

• Gene Names: RGS1; 1R20; BL34; IER1; IR20; HEL-S-87
• Synonyms: RGS1; RGS1 Antibody (N-term) Blocking Peptide; Regulator of G-protein signaling 1; B-cell activation protein BL34; Early response protein 1R20; 1R20; BL34; IER1; RGS1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human RGS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 209

• Tissue Location: B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RGS1 blocking peptide

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.

NCBI and Uniprot Product Information

• NCBI GI #: 229470360
• NCBI GeneID: 5996
• UniProt Accession #: Q08116; Q07918; Q9H1W2; B2RDM9; B4DZY0
• Molecular Weight: 19,134 Da
• NCBI Official Full Name: Regulator of G-protein signaling 1
• NCBI Official Synonym Full Names: regulator of G-protein signaling 1
• NCBI Official Symbol: RGS1
• NCBI Official Synonym Symbols: 1R20; BL34; IER1; IR20; HEL-S-87
• NCBI Protein Information: regulator of G-protein signaling 1
• UniProt Protein Name: Regulator of G-protein signaling 1
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS1
• UniProt Synonym Gene Names: 1R20; BL34; IER1; RGS1
• UniProt Entry Name: RGS1_HUMAN

NCBI Description

This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

Uniprot Description

RGS1: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: cytosol; extrinsic to internal side of plasma membrane; plasma membrane

Molecular Function: calmodulin binding; G-protein alpha-subunit binding; GTPase activator activity

Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; immune response; positive regulation of GTPase activity; signal transduction