RASSF2 blocking peptide

RASSF2 Blocking Peptide (Center)

• Gene Names: RASSF2; CENP-34; RASFADIN
• Synonyms: RASSF2; RASSF2 Blocking Peptide (Center); Ras association domain-containing protein 2; KIAA0168; RASSF2 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 123-136 of HUMAN RASSF2
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 326

• Cellular Location: Nucleus. Cytoplasm. Note: Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1
• Tissue Location: Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RASSF2 blocking peptide

Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.

NCBI and Uniprot Product Information

• NCBI GI #: 1723118
• NCBI GeneID: 9770
• UniProt Accession #: P50749; Q17S06; Q53HD0; Q6AHZ2; Q8IZA5; A6NIX9; A8K5Z3
• Molecular Weight: 17,879 Da
• NCBI Official Full Name: Ras association domain-containing protein 2
• NCBI Official Synonym Full Names: Ras association domain family member 2
• NCBI Official Symbol: RASSF2
• NCBI Official Synonym Symbols: CENP-34; RASFADIN
• NCBI Protein Information: ras association domain-containing protein 2
• UniProt Protein Name: Ras association domain-containing protein 2
• Protein Family: Ras association domain-containing protein
• UniProt Gene Name: RASSF2
• UniProt Entry Name: RASF2_HUMAN

NCBI Description

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

RASSF2: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.

Protein type: Cell cycle regulation; Tumor suppressor

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: cytoplasm; nucleus; protein complex

Molecular Function: protein binding; protein kinase activity

Biological Process: negative regulation of peptidyl-serine phosphorylation; positive regulation of apoptosis; positive regulation of JNK cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of protein kinase activity; protein stabilization