Rabbit anti-Human, Mouse RASSF2 Polyclonal Antibody | anti-RASSF2 antibody

RASSF2 Antibody (Center)

Cat. Num. AAA9215718

• Gene Names: RASSF2; CENP-34; RASFADIN
• Reactivity: Human, Mouse
• Applications: Western Blot
• Synonyms: RASSF2; Polyclonal Antibody; RASSF2 Antibody (Center); Purified Rabbit Polyclonal Antibody (Pab); Ras association domain-containing protein 2; KIAA0168; anti-RASSF2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This RASSF2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 123-156 amino acids from the Central region of human RASSF2.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 326

• Applicable Applications for anti-RASSF2 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000; WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-RASSF2 Antibody (Center) at 1:2000 dilutionLane 1: SH-SY5Y whole cell lysatesLane 2: Jurkat whole cell lysatesLane 3: human brain lysatesLane 4: mouse brain lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 38 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Western Blot (WB)

(All lanes : Anti-RASSF2 Antibody (Center) at 1:2000 dilutionLane 1: SH-SY5Y whole cell lysatesLane 2: Jurkat whole cell lysatesLane 3: Raji whole cell lysatesLane 4: human placenta lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 38 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-RASSF2 antibody

Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.

Product Categories/Family for anti-RASSF2 antibody

Cancer; Signal Transduction

References

Burbee D.G.,et al.Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases. Nagase T.,et al.DNA Res. 3:17-24(1996). Ota T.,et al.Nat. Genet. 36:40-45(2004). Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. Bechtel S.,et al.BMC Genomics 8:399-399(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 7661964
• NCBI GeneID: 9770
• NCBI Accession #: NP_055552.1
• NCBI GenBank Nucleotide #: NM_014737.2
• UniProt Accession #: P50749; Q17S06; Q53HD0; Q6AHZ2; Q8IZA5; A6NIX9; A8K5Z3
• Molecular Weight: 37790
• NCBI Official Full Name: ras association domain-containing protein 2
• NCBI Official Synonym Full Names: Ras association (RalGDS/AF-6) domain family member 2
• NCBI Official Symbol: RASSF2
• NCBI Official Synonym Symbols: CENP-34; RASFADIN
• NCBI Protein Information: ras association domain-containing protein 2
• UniProt Protein Name: Ras association domain-containing protein 2
• Protein Family: Ras association domain-containing protein
• UniProt Gene Name: RASSF2
• UniProt Synonym Gene Names: KIAA0168
• UniProt Entry Name: RASF2_HUMAN

NCBI Description

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

RASSF2: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.

Protein type: Tumor suppressor; Cell cycle regulation

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: protein complex; cytoplasm; nucleus

Molecular Function: protein binding; protein kinase activity

Biological Process: ossification; regulation of osteoclast differentiation; protein stabilization; regulation of osteoblast differentiation; positive regulation of apoptosis; positive regulation of protein kinase activity; negative regulation of peptidyl-serine phosphorylation; homeostasis of number of cells; positive regulation of JNK cascade; cell cycle; bone remodeling; protein amino acid phosphorylation; skeletal development; positive regulation of protein amino acid autophosphorylation