RASSF2 blocking peptide

RASSF2 Peptide

Cat. Num. AAA3006138

• Gene Names: RASSF2; CENP-34; RASFADIN
• Applications: Blocking
• Purity: Synthetic peptide RASSF2. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: RASSF2; RASSF2 Peptide; Ras association domain-containing protein 2; KIAA0168; RASSF2 blocking peptide

• Specificity: This peptide can be used with studies using MBS3006137 RASSF2 pAb.
• Purity/Purification: Synthetic peptide RASSF2. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 326

• Applicable Applications for RASSF2 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for RASSF2 blocking peptide

Ras is a small GTP-binding protein involved in many cellular processes, including proliferation, differentiation and apoptosis. Ras transmits signals of cell surface receptors by binding to a variety of effector molecules. In addition to the well-characterized effectors Raf and PI-3 kinase, Ras also interacts with a group of homologous, noncatalytic proteins composed of RASSF1, RASSF2, RASSF3, AD037 and Nore1. RASSF1 is a potential tumor suppressor gene that plays an important role in tumor pathogenesis. Nore1 binds to Ras in response to EGF or serum stimulation, but its function has yet to be determined. RASSF2 is a nuclear protein containing a Ras-associating domain and a SARAH domain. RASSF2 isoform A is inactivated in colorectal cancer cells by CpG island promoter hypermethylation.

NCBI and Uniprot Product Information

• NCBI GI #: 7661964
• NCBI GeneID: 9770
• NCBI Accession #: NP_055552.1
• NCBI GenBank Nucleotide #: NP_055552.1
• UniProt Accession #: P50749
• NCBI Official Full Name: ras association domain-containing protein 2
• NCBI Official Synonym Full Names: Ras association domain family member 2
• NCBI Official Symbol: RASSF2
• NCBI Official Synonym Symbols: CENP-34; RASFADIN
• NCBI Protein Information: ras association domain-containing protein 2
• UniProt Protein Name: Ras association domain-containing protein 2
• Protein Family: Ras association domain-containing protein
• UniProt Gene Name: RASSF2
• UniProt Synonym Gene Names: KIAA0168
• UniProt Entry Name: RASF2_HUMAN

NCBI Description

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

RASSF2: Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.

Protein type: Tumor suppressor; Cell cycle regulation

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: ossification; regulation of osteoclast differentiation; regulation of osteoblast differentiation; homeostasis of number of cells; bone remodeling; cell cycle; skeletal development