RASAL1 blocking peptide
RASAL1 Antibody (Center) Blocking peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]
Uniprot Description
RASAL1: a GTPase activating protein for Ras. Negatively regulates Ras (H-Ras) signaling activity. Two alternatively-spliced isoforms have been described. PITX1 inhibits tumorigenicity of the Ras pathway by inducing the transcription of RASAL1, which in turn inactivates Ras. Two alternatively-spliced isoforms have been described.
Protein type: GAPs, Ras; GAPs
Chromosomal Location of Human Ortholog: 12q23-q24
Cellular Component: cytosol; plasma membrane
Molecular Function: phospholipid binding
Biological Process: MAPKKK cascade; negative regulation of Ras protein signal transduction; signal transduction
Research Articles on RASAL1
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Product Notes
The RASAL1 rasal1 (Catalog #AAA9219147) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "RASAL1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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