RAB11A blocking peptide

RAB11A Antibody (Center) Blocking Peptide

• Gene Names: RAB11A; YL8
• Synonyms: RAB11A; RAB11A Antibody (Center) Blocking Peptide; Ras-related protein Rab-11A; Rab-11; YL8; RAB11; RAB11A blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 216

• Cellular Location: Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note: Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Recruited to phagosomes containing S.aureus or M.tuberculosis
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RAB11A blocking peptide

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 50402542
• NCBI GeneID: 8766
• UniProt Accession #: P62491; P24410; Q5TZN9; Q9JLX1; B2R4B6; B4DT13
• Molecular Weight: 17,659 Da
• NCBI Official Full Name: Ras-related protein Rab-11A
• NCBI Official Synonym Full Names: RAB11A, member RAS oncogene family
• NCBI Official Symbol: RAB11A
• NCBI Official Synonym Symbols: YL8
• NCBI Protein Information: ras-related protein Rab-11A
• UniProt Protein Name: Ras-related protein Rab-11A
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB11A
• UniProt Synonym Gene Names: RAB11; Rab-11
• UniProt Entry Name: RB11A_HUMAN

NCBI Description

The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Uniprot Description

RAB11A: Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3. Interacts with EXOC6 in a GTP- dependent manner. Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with SPE39//C14orf133. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. Belongs to the small GTPase superfamily. Rab family.

Protein type: Motility/polarity/chemotaxis; G protein, monomeric; G protein; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: centrosome; cleavage furrow; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; Golgi apparatus; kinetochore microtubule; multivesicular body; phagocytic vesicle; protein complex; recycling endosome; spindle pole; trans-Golgi network; vesicle

Molecular Function: GTPase activity; microtubule binding; myosin V binding; protein binding

Biological Process: astral microtubule organization and biogenesis; cytokinesis; establishment of vesicle localization; melanosome transport; mitotic metaphase plate congression; neurite development; renal water homeostasis; vesicle-mediated transport