PROX1 blocking peptide

PROX1 Antibody (C-term) Blocking Peptide

• Synonyms: PROX1; PROX1 Antibody (C-term) Blocking Peptide; Prospero homeobox protein 1; Homeobox prospero-like protein PROX1; PROX-1; PROX1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human PROX1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 737

• Cellular Location: Nucleus. Note: RORG promotes its nuclear localization
• Tissue Location: Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PROX1 blocking peptide

Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

NCBI and Uniprot Product Information

• NCBI GI #: 21359846
• NCBI GeneID: 5629
• NCBI Accession #: NP_002754
• NCBI GenBank Nucleotide #: NM_002763.4
• UniProt Accession #: Q92786; Q5SW76; Q8TB91; A6NK29; A8K2B1
• Molecular Weight: 83,203 Da
• NCBI Official Full Name: prospero homeobox protein 1
• NCBI Official Synonym Full Names: prospero homeobox 1
• NCBI Official Symbol: PROX1
• NCBI Protein Information: prospero homeobox protein 1
• UniProt Protein Name: Prospero homeobox protein 1
• Protein Family: Prospero homeobox protein
• UniProt Gene Name: PROX1
• UniProt Synonym Gene Names: PROX-1
• UniProt Entry Name: PROX1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Uniprot Description

PROX1: May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons. Belongs to the Prospero homeobox family.

Protein type: Nuclear receptor co-regulator; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: cytoplasm; nucleus

Molecular Function: DBD domain binding; DNA binding; LBD domain binding; ligand-dependent nuclear receptor binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; transcription corepressor activity; transcription factor activity

Biological Process: atrial cardiac muscle morphogenesis; brain development; cardiac muscle cell differentiation; cerebellar granule cell differentiation; dentate gyrus development; dorsal spinal cord development; embryonic retina morphogenesis in camera-type eye; kidney development; lens development in camera-type eye; liver development; lung development; lymphangiogenesis; muscle thin filament assembly; negative regulation of cell proliferation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of viral genome replication; neural tube development; neuron differentiation; olfactory placode formation; optic placode formation involved in camera-type eye; otic placode formation; pancreas development; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of cyclin-dependent protein kinase activity; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of circadian rhythm; regulation of gene expression; retina morphogenesis in camera-type eye; venous blood vessel morphogenesis; ventricular cardiac muscle morphogenesis; ventricular cardiac myofibril development