PRDM16 blocking peptide

PRDM16 Peptide

Cat. Num. AAA152900

• Gene Names: PRDM16; MEL1; LVNC8; PFM13; CMD1LL
• Applications: Blocking (BL)
• Synonyms: PRDM16; PRDM16 Peptide; MEL1; LVNC8; PFM13; CMD1LL; KIAA1675; PR domain zinc finger protein 16; PR domain-containing protein 16; PR domain containing 16; PRDM16 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 1,092

• Applicable Applications for PRDM16 blocking peptide: Blocking (BL)
• Application Notes: PRDM16 peptide is used for blocking the activity of PRDM16 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 17 amino acids near the carboxy terminus of human PRDM16.
• Preparation and Storage: Store PRDM16 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 55665817
• NCBI GeneID: 63976
• UniProt Accession #: Q9HAZ2; Q8WYJ9; Q9C0I8; A6NHQ8; B1AJP7; B1AJP8; B1AJP9; B1WB48
• Molecular Weight: 120,338 Da
• NCBI Official Synonym Full Names: PR domain containing 16
• NCBI Official Symbol: PRDM16
• NCBI Official Synonym Symbols: MEL1; LVNC8; PFM13; CMD1LL
• NCBI Protein Information: PR domain zinc finger protein 16
• UniProt Protein Name: PR domain zinc finger protein 16
• Protein Family: PR domain zinc finger protein
• UniProt Gene Name: PRDM16
• UniProt Synonym Gene Names: KIAA1675; MEL1; PFM13; MDS1/EVI1-like gene 1
• UniProt Entry Name: PRD16_HUMAN

NCBI Description

The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

PRDM16: binds DNA and functions as a transcriptional regulator. A repressor of TGF-beta signaling. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Interacts with HDAC1, SKI, SMAD2 and SMAD3; the interaction with SKI promotes the recruitment of SMAD3-HDAC1 complex on the promoter of TGF-beta target genes. A chromosomal aberration involving PRDM16 is found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Reciprocal translocation t(1;3)(p36;q21). Isoform 4 is specifically expressed in adult T-cell leukemia. Four human isoforms are produced by alternative promoter usage and alternative splicing

Protein type: Methyltransferase, protein lysine, predicted; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 1p36.23-p33

Cellular Component: transcriptional repressor complex; nucleus

Molecular Function: protein binding; transcription activator binding; sequence-specific DNA binding; metal ion binding; transcription coactivator activity; SMAD binding

Biological Process: tongue development; transcription, DNA-dependent; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; palate development; negative regulation of granulocyte differentiation; regulation of cellular respiration; neurogenesis; white fat cell differentiation; brown fat cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of transcription, DNA-dependent

Disease: Left Ventricular Noncompaction 8