PPM1D blocking peptide

PPM1D Peptide

Cat. Num. AAA154057

• Gene Names: PPM1D; WIP1; PP2C-DELTA
• Applications: Blocking (BL)
• Synonyms: PPM1D; PPM1D Peptide; Protein phosphatase Mg2+/Mn2+ dependent 1D; p53-induced protein phosphatase 1; PP2C-DELTA; Protein phosphatase 1D; WIP1 ; PPM1D blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 605

• Applicable Applications for PPM1D blocking peptide: Blocking (BL)
• Application Notes: PPM1D peptide is used for blocking the activity of PPM1D antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 18 amino acid peptide near the carboxy terminus of human PPM1D.
• Preparation and Storage: Store PPM1D peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 4505997
• NCBI GeneID: 8493
• NCBI Accession #: NP_003611
• NCBI GenBank Nucleotide #: NM_003620.3
• UniProt Accession #: Q8IVR6; Q53XP4; Q6P991; O15297
• Molecular Weight: 47,211 Da
• NCBI Official Full Name: protein phosphatase 1D
• NCBI Official Synonym Full Names: protein phosphatase, Mg2+/Mn2+ dependent, 1D
• NCBI Official Symbol: PPM1D
• NCBI Official Synonym Symbols: WIP1; PP2C-DELTA
• NCBI Protein Information: protein phosphatase 1D; protein phosphatase Wip1; wild-type p53-induced phosphatase 1; protein phosphatase 2C delta isoform; protein phosphatase 1D magnesium-dependent, delta isoform
• UniProt Protein Name: Protein phosphatase 1D
• Protein Family: Protein phosphatase
• UniProt Gene Name: PPM1D
• UniProt Synonym Gene Names: WIP1; PP2C-delta
• UniProt Entry Name: PPM1D_HUMAN

NCBI Description

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]

Uniprot Description

PPM1D: a magnesium-dependent Ser/Thr phosphatase. A p53-induced phosphatase that interacts with the nuclear isoform of uracil DNA glycosylase, UNG2, and suppresses base excision repair. Might contribute to growth inhibitory pathways activated in response to DNA damage in a p53-dependent manner.

Protein type: Nuclear receptor co-regulator; EC 3.1.3.16; Motility/polarity/chemotaxis; Cell cycle regulation; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: nucleus

Molecular Function: protein binding; metal ion binding; protein serine/threonine phosphatase activity

Biological Process: negative regulation of cell proliferation; response to radiation; response to bacterium; protein amino acid dephosphorylation; G2/M transition of mitotic cell cycle

Disease: Breast Cancer