POFUT1 blocking peptide

POFUT1 Peptide

Cat. Num. AAA152637

• Gene Names: POFUT1; DDD2; FUT12; O-FUT; OFUCT1; O-Fuc-T; O-FucT-1
• Applications: Blocking (BL)
• Synonyms: POFUT1; POFUT1 Peptide; DDD2; FUT12; O-FUT; OFUCT1; O-Fuc-T; O-FucT-1; KIAA0180; GDP-fucose protein O-fucosyltransferase 1; Peptide-O-fucosyltransferase 1; protein O-fucosyltransferase 1; POFUT1 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 388

• Applicable Applications for POFUT1 blocking peptide: Blocking (BL)
• Application Notes: POFUT1 peptide is used for blocking the activity of POFUT1 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 16 amino acids near the amino terminus of human POFUT1
• Preparation and Storage: Store POFUT1 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 27436889
• NCBI GeneID: 23509
• NCBI Accession #: NP_056167
• NCBI GenBank Nucleotide #: NM_015352.1
• UniProt Accession #: Q9H488; Q14685; Q5W185; Q9BW76; A8K4R8; E1P5M4
• Molecular Weight: 22,338 Da
• NCBI Official Full Name: GDP-fucose protein O-fucosyltransferase 1 isoform 1
• NCBI Official Synonym Full Names: protein O-fucosyltransferase 1
• NCBI Official Symbol: POFUT1
• NCBI Official Synonym Symbols: DDD2; FUT12; O-FUT; OFUCT1; O-Fuc-T; O-FucT-1
• NCBI Protein Information: GDP-fucose protein O-fucosyltransferase 1; o-fucosyltransferase protein; peptide-O-fucosyltransferase 1
• UniProt Protein Name: GDP-fucose protein O-fucosyltransferase 1
• UniProt Gene Name: POFUT1
• UniProt Synonym Gene Names: FUT12; KIAA0180; O-FucT-1
• UniProt Entry Name: OFUT1_HUMAN

NCBI Description

This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

POFUT1: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in EGF domains. Plays a crucial role in Notch signaling. Belongs to the glycosyltransferase 68 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.4.1.221

Chromosomal Location of Human Ortholog: 20q11

Cellular Component: membrane; endoplasmic reticulum

Molecular Function: peptide-O-fucosyltransferase activity; fucosyltransferase activity

Biological Process: fucose metabolic process; nervous system development; protein amino acid O-linked glycosylation; somitogenesis; Notch signaling pathway; embryonic development; O-glycan processing; regulation of transcription, DNA-dependent; heart development; angiogenesis

Disease: Dowling-degos Disease 2