PNN blocking peptide

PNN Antibody (Center) Blocking peptide

• Gene Names: PNN; DRS; DRSP; SDK3; memA
• Synonyms: PNN; PNN Antibody (Center) Blocking peptide; Pinin; 140 kDa nuclear and cell adhesion-related phosphoprotein; Desmosome-associated protein; Domain-rich serine protein; DRS protein; DRSP; Melanoma metastasis clone A protein; Nuclear protein SDK3; SR-like protein; DRS; MEMA; PNN blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 717

• Cellular Location: Nucleus speckle. Cell junction, desmosome. Note: Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein
• Tissue Location: Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PNN blocking peptide

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell- cell adhesion. Potential tumor suppressor for renal cell carcinoma.

NCBI and Uniprot Product Information

• NCBI GI #: 73921750
• NCBI GeneID: 5411
• UniProt Accession #: Q9H307; O60899; Q53EM7; Q6P5X4; Q7KYL1; Q99738; Q9UHZ9; Q9UQR9; B4DZX8
• Molecular Weight: 67,005 Da
• NCBI Official Full Name: Pinin
• NCBI Official Synonym Full Names: pinin, desmosome associated protein
• NCBI Official Symbol: PNN
• NCBI Official Synonym Symbols: DRS; DRSP; SDK3; memA
• NCBI Protein Information: pinin
• UniProt Protein Name: Pinin
• Protein Family: Pinin
• UniProt Gene Name: PNN
• UniProt Synonym Gene Names: DRS; MEMA; DRS protein; DRSP
• UniProt Entry Name: PININ_HUMAN

Uniprot Description

PNN: Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. Belongs to the pinin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Spliceosome; Tumor suppressor; RNA splicing; RNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 14q21.1

Cellular Component: intercellular junction; intermediate filament; membrane; nucleoplasm; plasma membrane

Biological Process: cell adhesion; nuclear mRNA splicing, via spliceosome