PLXNA2 blocking peptide

PLXNA2 Blocking Peptide

Cat. Num. AAA9628781

• Gene Names: PLXNA2; OCT; PLXN2
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: PLXNA2; PLXNA2 Blocking Peptide; Plexin-A2; PlexinA2; PLXA2; PLXA2_HUMAN; Semaphorin receptor OCT; PLXNA2 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for PLXNA2 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PLXNA2 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 113722116
• NCBI GeneID: 5362
• NCBI Accession #: NP_079455.3
• NCBI GenBank Nucleotide #: NM_025179.3
• UniProt Accession #: O75051; Q6UX61; Q96GN9; Q9BRL1; Q9UIW1; A2RTX9; B2RMX7
• Molecular Weight: 61,649 Da
• NCBI Official Full Name: plexin-A2
• NCBI Official Synonym Full Names: plexin A2
• NCBI Official Symbol: PLXNA2
• NCBI Official Synonym Symbols: OCT; PLXN2
• NCBI Protein Information: plexin-A2
• UniProt Protein Name: Plexin-A2
• Protein Family: Plexin
• UniProt Gene Name: PLXNA2
• UniProt Synonym Gene Names: KIAA0463; OCT; PLXN2

NCBI Description

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]

Uniprot Description

Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm ().