PLA2G3 blocking peptide

PLA2G3 Antibody (C-term) Blocking Peptide

• Gene Names: PLA2G3; SPLA2III; sPLA2-III; GIII-SPLA2
• Synonyms: PLA2G3; PLA2G3 Antibody (C-term) Blocking Peptide; Group 3 secretory phospholipase A2; Group III secretory phospholipase A2; GIII sPLA2; sPLA2-III; Phosphatidylcholine 2-acylhydrolase 3; PLA2G3 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 509

• Cellular Location: Secreted. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
• Tissue Location: Expressed in kidney, heart, liver, and skeletal muscle. Also present in placenta and peripheral blood leukocytes. Not detected in brain, colon, thymus, spleen and small intestine. In lung, expressed in bronchial epithelial cells and alveolar macrophages, but scarcely detected in alveolar epithelium, arterial walls and interstitial fibroblasts (at protein level). In joints of osteoarthritis and rheumatoid arthritis, expressed in endothelial cells (at protein level). In normal heart, detected in some vessels. In myocardial tissues with acute infarction, expressed in vascular endothelial cells adjacent to cardiomyocytes and those in lesions with granulation Expression in cardiomyocytes is scarce (at protein level). In uterus, breast and colon cancers, detected in tumor cells and neighboring microvascular endothelium, but not in normal glandular tissues (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PLA2G3 blocking peptide

PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl- phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1- palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 317373314
• NCBI GeneID: 50487
• UniProt Accession #: Q9NZ20; O95768
• Molecular Weight: 57,167 Da
• NCBI Official Full Name: Group 3 secretory phospholipase A2
• NCBI Official Synonym Full Names: phospholipase A2 group III
• NCBI Official Symbol: PLA2G3
• NCBI Official Synonym Symbols: SPLA2III; sPLA2-III; GIII-SPLA2
• NCBI Protein Information: group 3 secretory phospholipase A2
• UniProt Protein Name: Group 3 secretory phospholipase A2
• Protein Family: Group 3 secretory phospholipase
• UniProt Gene Name: PLA2G3
• UniProt Synonym Gene Names: GIII sPLA2; sPLA2-III
• UniProt Entry Name: PA2G3_HUMAN

NCBI Description

This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]

Uniprot Description

PLA2G3: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl- phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1- palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis. Belongs to the phospholipase A2 family.

Protein type: Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - ether lipid; EC 3.1.1.4; Phospholipase; Lipid Metabolism - glycerophospholipid

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: centriole; extracellular region; extracellular space

Molecular Function: calcium-dependent phospholipase A2 activity; phospholipase A2 activity

Biological Process: phospholipid metabolic process