PEVR1 blocking peptide

PEVR1 Blocking Peptide

Cat. Num. AAA9625310

• Gene Names: SLC52A2; PAR1; RFT3; RFVT2; hRFT3; BVVLS2; GPCR41; GPR172A; D15Ertd747e
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: PEVR1; PEVR1 Blocking Peptide; GPR172A; hRFT3; PAR1; PERV-A receptor 1; Porcine endogenous retrovirus A receptor 1; Protein GPR172A; RFT3; RFT3_HUMAN; Riboflavin transporter 3; PEVR1 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for PEVR1 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PEVR1 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 359465547
• NCBI GeneID: 79581
• NCBI Accession #: NP_001240744.1
• NCBI GenBank Nucleotide #: NM_001253815.1
• UniProt Accession #: Q9HAB3; Q86UT1; A8K6B6; D3DWL8; G1UCY1
• Molecular Weight: 45,777 Da
• NCBI Official Full Name: solute carrier family 52, riboflavin transporter, member 2
• NCBI Official Synonym Full Names: solute carrier family 52, riboflavin transporter, member 2
• NCBI Official Symbol: SLC52A2
• NCBI Official Synonym Symbols: PAR1; RFT3; RFVT2; hRFT3; BVVLS2; GPCR41; GPR172A; D15Ertd747e
• NCBI Protein Information: solute carrier family 52, riboflavin transporter, member 2; PERV-A receptor 1; riboflavin transporter 3; G protein-coupled receptor 172A; porcine endogenous retrovirus A receptor 1; putative G-protein coupled receptor GPCR41
• UniProt Protein Name: Solute carrier family 52, riboflavin transporter, member 2
• UniProt Gene Name: SLC52A2
• UniProt Synonym Gene Names: GPR172A; PAR1; RFT3; PERV-A receptor 1; hRFT3
• UniProt Entry Name: S52A2_HUMAN

NCBI Description

This gene encodes a membrane protein which belongs to the riboflavin transporter family. In humans, riboflavin must be obtained by intestinal absorption because it cannot be synthesized by the body. The water-soluble vitamin riboflavin is processed to the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) which then act as intermediaries in many cellular metabolic reactions. Paralogous members of the riboflavin transporter gene family are located on chromosomes 17 and 20. Unlike other members of this family, this gene has higher expression in brain tissue than small intestine. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene have been associated with Brown-Vialetto-Van Laere syndrome 2 - an autosomal recessive progressive neurologic disorder characterized by deafness, bulbar dysfunction, and axial and limb hypotonia. [provided by RefSeq, Jul 2012]

Uniprot Description

GPR172A: Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). Defects in SLC52A2 are the cause of Brown-Vialetto-Van Laere syndrome type 2 (BVVLS2). An autosomal recessive progressive neurologic disorder characterized by early childhood onset of sensorineural deafness, bulbar dysfunction, and severe diffuse muscle weakness and wasting resulting in respiratory insufficiency and loss of independent ambulation. Because it results from a defect in riboflavin metabolism, some patients may benefit from high-dose riboflavin supplementation. Belongs to the riboflavin transporter family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: integral to plasma membrane

Molecular Function: viral receptor activity; riboflavin transporter activity

Biological Process: entry of virus into host cell; riboflavin transport

Disease: Brown-vialetto-van Laere Syndrome 2