PELO blocking peptide
PELO Antibody Antigenic Blocking Peptide
Is necessary in cell division for normal chromosome segregation and genomic stability. It may recognize stalled ribosomes and trigger endonucleolytic cleavage of the mRNA, and may hav ribonuclease activity.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]
Uniprot Description
PELO: Required for normal chromosome segregation during cell division and genomic stability. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
Protein type: EC 3.1.-.-; Hydrolase
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component: cytoplasm; nucleus
Molecular Function: endonuclease activity; metal ion binding; protein binding
Biological Process: cell cycle; cell division; cell proliferation; chromosome organization and biogenesis
Research Articles on PELO
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Product Notes
The PELO pelo (Catalog #AAA544239) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PELO can be used in a range of immunoassay formats including, but not limited to, Immunodepletion, Immunocompetition. Western Blot: 1:500. Researchers should empirically determine the suitability of the PELO pelo for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PELO, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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