PELI3 blocking peptide

PELI3 Antibody (N-term) Blocking peptide

• Synonyms: PELI3; PELI3 Antibody (N-term) Blocking peptide; E3 ubiquitin-protein ligase pellino homolog 3; Pellino-3; 632-; PELI3 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of PELI3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 469

• Tissue Location: Highly expressed in brain, heart and testis, and at lower level in kidney, liver, lung, placenta, small intestine, spleen and stomach. Isoform 1 is not expressed in lung
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PELI3 blocking peptide

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation.

NCBI and Uniprot Product Information

• NCBI GI #: 37999712
• NCBI GeneID: 246330
• UniProt Accession #: Q8N2H9; Q8N3E1; Q8N9Q6; Q8TAW7; Q8TED5
• Molecular Weight: 35,339 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase pellino homolog 3
• NCBI Official Synonym Full Names: pellino E3 ubiquitin protein ligase family member 3
• NCBI Official Symbol: PELI3
• NCBI Protein Information: E3 ubiquitin-protein ligase pellino homolog 3
• UniProt Protein Name: E3 ubiquitin-protein ligase pellino homolog 3
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: PELI3
• UniProt Synonym Gene Names: Pellino-3
• UniProt Entry Name: PELI3_HUMAN

NCBI Description

The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

Uniprot Description

PELI3: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. Belongs to the pellino family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.19; EC 6.3.2.-; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: cytosol

Molecular Function: protein binding