PDCD6 blocking peptide

PDCD6 Blocking Peptide (N-term)

• Gene Names: PDCD6; ALG2; ALG-2; PEF1B
• Synonyms: PDCD6; PDCD6 Blocking Peptide (N-term); Programmed cell death protein 6; Apoptosis-linked gene 2 protein; Probable calcium-binding protein ALG-2; ALG2; PDCD6 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 34-47 of HUMAN PDCD6
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 191

• Cellular Location: Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Endosome. Note: Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PDCD6 blocking peptide

Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5.

NCBI and Uniprot Product Information

• NCBI GI #: 7019485
• NCBI GeneID: 10016
• NCBI Accession #: NP_037364.1
• NCBI GenBank Nucleotide #: NM_013232.3
• UniProt Accession #: O75340; Q2YDC2; Q5TZS0; B2RD16; E7ESR3
• Molecular Weight: 7,349 Da
• NCBI Official Full Name: programmed cell death protein 6 isoform 1
• NCBI Official Synonym Full Names: programmed cell death 6
• NCBI Official Symbol: PDCD6
• NCBI Official Synonym Symbols: ALG2; ALG-2; PEF1B
• NCBI Protein Information: programmed cell death protein 6
• UniProt Protein Name: Programmed cell death protein 6
• Protein Family: Programmed cell death protein
• UniProt Gene Name: PDCD6
• UniProt Synonym Gene Names: ALG2
• UniProt Entry Name: PDCD6_HUMAN

NCBI Description

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]

Uniprot Description

PDCD6: Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway. Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; nucleus

Molecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; calcium-dependent protein binding; identical protein binding; molecular adaptor activity; protein anchor; protein binding; protein dimerization activity

Biological Process: intracellular protein transport; negative regulation of protein kinase B signaling cascade; negative regulation of TOR signaling pathway; negative regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of angiogenesis; positive regulation of caspase activity; positive regulation of endothelial cell proliferation; response to calcium ion