Pael-R (GPR37) Blocking Peptide | GPR37 blocking peptide

Pael-R (GPR37) Antibody (N-term) Blocking Peptide

• Gene Names: GPR37; PAELR; EDNRBL; hET(B)R-LP
• Synonyms: Pael-R (GPR37); Pael-R (GPR37) Antibody (N-term) Blocking Peptide; Prosaposin receptor GPR37; Endothelin B receptor-like protein 1; ETBR-LP-1; G-protein coupled receptor 37; Parkin-associated endothelin receptor-like receptor; PAELR; GPR37; GPR37 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the GPR37 region of human Pael-R (GPR37). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 613

• Cellular Location: Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein
• Tissue Location: Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GPR37 blocking peptide

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

NCBI and Uniprot Product Information

• NCBI GI #: 4885323
• NCBI GeneID: 2861
• NCBI Accession #: NP_005293
• NCBI GenBank Nucleotide #: NM_005302.3
• UniProt Accession #: O15354; O00348; O14768; Q8TD39; A4D0Y6
• Molecular Weight: 67,114 Da
• NCBI Official Full Name: prosaposin receptor GPR37
• NCBI Official Synonym Full Names: G protein-coupled receptor 37
• NCBI Official Symbol: GPR37
• NCBI Official Synonym Symbols: PAELR; EDNRBL; hET(B)R-LP
• NCBI Protein Information: prosaposin receptor GPR37
• UniProt Protein Name: Prosaposin receptor GPR37
• Protein Family: Prosaposin receptor
• UniProt Gene Name: GPR37
• UniProt Synonym Gene Names: ETBR-LP-1; PAELR
• UniProt Entry Name: GPR37_HUMAN

NCBI Description

This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]

Uniprot Description

GPR37: Orphan receptor. May have a unique functional role in the central nervous system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: endoplasmic reticulum; integral to plasma membrane; plasma membrane; receptor complex; ubiquitin ligase complex

Molecular Function: G-protein coupled receptor activity; heat shock protein binding; Hsp70 protein binding; peptide binding; peptide receptor activity, G-protein coupled; protein binding; ubiquitin protein ligase binding

Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; positive regulation of MAPKKK cascade