PACSIN3 blocking peptide

PACSIN3 Antibody (N-term) Blocking Peptide

• Gene Names: PACSIN3; SDPIII
• Synonyms: PACSIN3; PACSIN3 Antibody (N-term) Blocking Peptide; Protein kinase C and casein kinase substrate in neurons protein 3; SH3 domain-containing protein 6511; PACSIN3 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human PACSIN3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 424

• Cellular Location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Detected at the inner aspect of the plasma membrane in myotubes
• Tissue Location: Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PACSIN3 blocking peptide

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 22256967
• NCBI GeneID: 29763
• UniProt Accession #: Q9UKS6; Q9H331; Q9NWV9; A6NH84
• Molecular Weight: 48,487 Da
• NCBI Official Full Name: Protein kinase C and casein kinase substrate in neurons protein 3
• NCBI Official Synonym Full Names: protein kinase C and casein kinase substrate in neurons 3
• NCBI Official Symbol: PACSIN3
• NCBI Official Synonym Symbols: SDPIII
• NCBI Protein Information: protein kinase C and casein kinase substrate in neurons protein 3
• UniProt Protein Name: Protein kinase C and casein kinase substrate in neurons protein 3
• Protein Family: Protein kinase C and casein kinase II substrate protein
• UniProt Gene Name: PACSIN3
• UniProt Entry Name: PACN3_HUMAN

NCBI Description

This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Description

PACSIN3: May play a role in vesicle formation and transport. Belongs to the PACSIN family.

Protein type: Adaptor/scaffold; Vesicle

Chromosomal Location of Human Ortholog: 11p12-p11.12

Cellular Component: cytoplasm; endosome; nucleoplasm; plasma membrane

Molecular Function: calcium channel inhibitor activity; cytoskeletal protein binding; lipid binding; protein binding

Biological Process: negative regulation of calcium ion transport; negative regulation of endocytosis; positive regulation of membrane protein ectodomain proteolysis; regulation of endocytosis