PAAF1 blocking peptide

PAAF1 Antibody (N-term) Blocking Peptide

• Gene Names: PAAF1; PAAF; Rpn14; WDR71
• Synonyms: PAAF1; PAAF1 Antibody (N-term) Blocking Peptide; Proteasomal ATPase-associated factor 1; Protein G-16; WD repeat-containing protein 71; WDR71; PAAF1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 392

• Tissue Location: Ubiquitously expressed, with highest levels in kidney, brain and testis.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PAAF1 blocking peptide

Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation.

NCBI and Uniprot Product Information

• NCBI GI #: 97217547
• NCBI GeneID: 80227
• UniProt Accession #: Q9BRP4; Q4G165; Q53HS9; Q7Z500; Q8TBU6; Q9HAB6; A6NDR5; B4DPB0; B7ZAS9
• Molecular Weight: 29,982 Da
• NCBI Official Full Name: Proteasomal ATPase-associated factor 1
• NCBI Official Synonym Full Names: proteasomal ATPase associated factor 1
• NCBI Official Symbol: PAAF1
• NCBI Official Synonym Symbols: PAAF; Rpn14; WDR71
• NCBI Protein Information: proteasomal ATPase-associated factor 1
• UniProt Protein Name: Proteasomal ATPase-associated factor 1
• Protein Family: Proteasomal ATPase-associated factor
• UniProt Gene Name: PAAF1
• UniProt Synonym Gene Names: WDR71
• UniProt Entry Name: PAAF1_HUMAN

NCBI Description

This gene encodes a WD repeat-containing protein involved in regulation of association of proteasome components. During HIV infection, the encoded protein is thought to promote provirus transcription through recruitment of the 19S regulatory complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

Uniprot Description

PAAF1: Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Belongs to the WD repeat PAAF1/RPN14 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: proteasome complex

Molecular Function: protein binding