p-GluR1 blocking peptide

p-GluR1 (S849) Peptide

Cat. Num. AAA3005331

• Gene Names: GRIA1; GLUH1; GLUR1; GLURA; GluA1; HBGR1
• Applications: Blocking
• Purity: Synthetic peptide p-GluR1 (S849). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: p-GluR1; p-GluR1 (S849) Peptide; GLUR 1; GLUR A; AMPA 1; AMPA selective glutamate receptor 1; AMPA-selective glutamate receptor 1; GluA1; GLUH1; GluR K1; GluR-1; GluR-A; GluR-K1; GLUR1; GLURA; GluRK1; Glutamate receptor 1; Glutamate receptor ionotropic AMPA 1; Glutamate receptor ionotropic; Glutamate receptor; ionotropic; Gria1; GRIA1; HBGR1; MGC133252; p-GluR1 blocking peptide

• Specificity: This peptide can be used with studies using MBS3005330 p-GluR1 (S849) pAb.
• Purity/Purification: Synthetic peptide p-GluR1 (S849). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 906

• Applicable Applications for p-GluR1 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for p-GluR1 blocking peptide

Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions.

NCBI and Uniprot Product Information

• NCBI GI #: 167001419
• NCBI GeneID: 2890
• NCBI Accession #: NP_000818.2
• NCBI GenBank Nucleotide #: NP_000818.2
• UniProt Accession #: P42261
• NCBI Official Full Name: glutamate receptor 1 isoform 1
• NCBI Official Synonym Full Names: glutamate ionotropic receptor AMPA type subunit 1
• NCBI Official Symbol: GRIA1
• NCBI Official Synonym Symbols: GLUH1; GLUR1; GLURA; GluA1; HBGR1
• NCBI Protein Information: glutamate receptor 1
• UniProt Protein Name: Glutamate receptor 1
• UniProt Gene Name: GRIA1
• UniProt Synonym Gene Names: GLUH1; GLUR1; GluR-1; GluA1
• UniProt Entry Name: GRIA1_HUMAN

NCBI Description

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

GluR1: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation.

Protein type: Membrane protein, integral; Channel, ligand-gated; Channel, calcium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: postsynaptic membrane; synaptic vesicle; endoplasmic reticulum membrane; recycling endosome; cell surface; cell soma; postsynaptic density; dendrite; dendritic spine; plasma membrane; cell junction

Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; glutamate receptor activity; PDZ domain binding

Biological Process: synaptic transmission, glutamatergic; synaptic transmission; long-term memory; ionotropic glutamate receptor signaling pathway; receptor internalization; signal transduction