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OPRK1 blocking peptide

OPRK1 Blocking Peptide (Center)

Gene Names
OPRK1; KOR; OPRK; KOR-1; K-OR-1
Synonyms
OPRK1; OPRK1 Blocking Peptide (Center); Kappa-type opioid receptor; K-OR-1; KOR-1; OPRK; OPRK1 blocking peptide
Ordering
Specificity
The synthetic peptide sequence is selected from aa 196-209 of HUMAN OPRK1
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
380
Cellular Location
Cell membrane; Multi-pass membrane protein
Tissue Location
Detected in brain and placenta.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for OPRK1 blocking peptide
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
33,319 Da
NCBI Official Full Name
kappa-type opioid receptor isoform 1
NCBI Official Synonym Full Names
opioid receptor kappa 1
NCBI Official Symbol
OPRK1
NCBI Official Synonym Symbols
KOR; OPRK; KOR-1; K-OR-1
NCBI Protein Information
kappa-type opioid receptor
UniProt Protein Name
Kappa-type opioid receptor
UniProt Gene Name
OPRK1
UniProt Synonym Gene Names
OPRK; K-OR-1; KOR-1
UniProt Entry Name
OPRK_HUMAN

NCBI Description

This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016]

Uniprot Description

KOR-1: kappa-type opioid receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q11.2

Cellular Component: integral to membrane; integral to plasma membrane; neuron projection; plasma membrane

Molecular Function: neuropeptide binding; opioid receptor activity; protein binding

Biological Process: behavior; defense response to virus; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; locomotory behavior; neuropeptide signaling pathway; opioid receptor, adenylate cyclase inhibiting pathway; regulation of saliva secretion; sensory perception; sensory perception of pain; synaptic transmission

Research Articles on OPRK1

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Product Notes

The OPRK1 oprk1 (Catalog #AAA9228897) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "OPRK1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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