OPCML blocking peptide

OPCML Antibody(Center) Blocking peptide

• Gene Names: OPCML; OPCM; OBCAM; IGLON1
• Synonyms: OPCML; OPCML Antibody(Center) Blocking peptide; Opioid-binding protein/cell adhesion molecule; OBCAM; Opioid-binding cell adhesion molecule; IgLON family member 1; IGLON1; OPCML blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 345

• Cellular Location: Cell membrane; Lipid-anchor, GPI-anchor
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for OPCML blocking peptide

Binds opioids in the presence of acidic lipids; probably involved in cell contact.

NCBI and Uniprot Product Information

• NCBI GI #: 2497326
• NCBI GeneID: 4978
• UniProt Accession #: Q14982; Q17RN7; Q7Z3W6; B2CZX2; B7ZLQ1
• Molecular Weight: 38,849 Da
• NCBI Official Full Name: Opioid-binding protein/cell adhesion molecule
• NCBI Official Synonym Full Names: opioid binding protein/cell adhesion molecule like
• NCBI Official Symbol: OPCML
• NCBI Official Synonym Symbols: OPCM; OBCAM; IGLON1
• NCBI Protein Information: opioid-binding protein/cell adhesion molecule
• UniProt Protein Name: Opioid-binding protein/cell adhesion molecule
• Protein Family: Opioid-binding protein/cell adhesion molecule
• UniProt Gene Name: OPCML
• UniProt Synonym Gene Names: IGLON1; OBCAM; OBCAM; OPCML; Opioid-binding cell adhesion molecule
• UniProt Entry Name: OPCM_HUMAN

NCBI Description

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Description

OPCML: Binds opioids in the presence of acidic lipids; probably involved in cell contact. Defects in OPCML are a cause of susceptibility to ovarian cancer (OC). Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late- stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Belongs to the immunoglobulin superfamily. IgLON family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q25

Biological Process: neuron recognition

Disease: Ovarian Cancer