Oct-2 blocking peptide

Oct-2 (H3) Peptide

Cat. Num. AAA3000757

• Gene Names: POU2F2; OCT2; OTF2; Oct-2
• Applications: Blocking
• Purity: Synthetic peptide Oct-2 (H3). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Oct-2; Oct-2 (H3) Peptide; POU2F2; OCT2; OTF-2; OTF2; Oct-2 blocking peptide

• Specificity: This peptide can be used with studies using MBS3000756 Oct-2 (H3) pAb.
• Purity/Purification: Synthetic peptide Oct-2 (H3). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 479

• Applicable Applications for Oct-2 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for Oct-2 blocking peptide

Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines, cationic drugs and other xenobiotics. In humans, OCT1 is primarily expressed in the liver while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT3, also known as extraneuronal monoamine transporter, is widely expressed in different regions of the brain including the hippocampus, cerebellum and cerebral cortex. OCT3 mediates the uptake of several neuroactive agents, including dopamine, and may play an important role in the disposition of neurotransmitters and cationic neurotoxins in the brain. The genes encoding human OCT1-3 map to a conserved cluster at chromosome 6q26-q27.

NCBI and Uniprot Product Information

• NCBI GI #: 333360875
• NCBI GeneID: 5452
• NCBI Accession #: NP_001193954.1
• NCBI GenBank Nucleotide #: NP_001193954.1
• UniProt Accession #: P09086
• NCBI Official Full Name: POU domain, class 2, transcription factor 2 isoform 1
• NCBI Official Synonym Full Names: POU class 2 homeobox 2
• NCBI Official Symbol: POU2F2
• NCBI Official Synonym Symbols: OCT2; OTF2; Oct-2
• NCBI Protein Information: POU domain, class 2, transcription factor 2
• UniProt Protein Name: POU domain, class 2, transcription factor 2
• UniProt Gene Name: POU2F2
• UniProt Synonym Gene Names: OCT2; OTF2; Oct-2; OTF-2
• UniProt Entry Name: PO2F2_HUMAN

NCBI Description

The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

Oct2: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. Belongs to the POU transcription factor family. Class- 2 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein domain specific binding; sequence-specific DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; immunoglobulin secretion during immune response; mature B cell differentiation; positive regulation of transcription, DNA-dependent; cell maturation; humoral immune response