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OATP1 blocking peptide

OATP1 (N286) Peptide

Gene Names
SLCO1A2; OATP; OATP-A; OATP1A2; SLC21A3
Applications
Blocking
Purity
Synthetic peptide OATP1 (N286). (Note: the amino acid sequence is proprietary).
The purity is >98%.
Synonyms
OATP1; OATP1 (N286) Peptide; OATP; OATP-1; OATP-A; OATP1A2; Organic anion-transporting polypeptide 1; SLC21A3; SLCO1A2; SO1A2; OATP1 blocking peptide
Ordering
For Research Use Only!
Specificity
This peptide can be used with studies using MBS3004473 OATP1 (N286) pAb.
Purity/Purification
Synthetic peptide OATP1 (N286). (Note: the amino acid sequence is proprietary).
The purity is >98%.
Form/Format
1 mg/ml in DI water.
Sequence Length
670
Applicable Applications for OATP1 blocking peptide
Blocking
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Related Product Information for OATP1 blocking peptide
The organic anion transporting polypeptides, OATP-A (also designated OATP1, OATP1A2 and SLC21A3) and OATP-C (also designated OATP2, SLC21A6 and LST1), mediate hepatic uptake of cardiac glycosides. The expression of OATP-C, but not OATP-A, is inducible by phenobarbital and pregnenolone-16a-carbonitrile, resulting in the increased capacity of the liver to extract cardiac glycosides from the plasma. OATP-A is expressed in liver and kidney and helps mediate sodium-independent uptake of the anionic steroid conjugates dehydroepiandrosterone sulfate, estradiol-17-glucuronide and prostaglandin. OATP-C is exclusively expressed in liver and is localized to the basolateral hepatocyte membrane.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
solute carrier organic anion transporter family member 1A2
NCBI Official Synonym Full Names
solute carrier organic anion transporter family member 1A2
NCBI Official Symbol
SLCO1A2
NCBI Official Synonym Symbols
OATP; OATP-A; OATP1A2; SLC21A3
NCBI Protein Information
solute carrier organic anion transporter family member 1A2
UniProt Protein Name
Solute carrier organic anion transporter family member 1A2
UniProt Gene Name
SLCO1A2
UniProt Synonym Gene Names
OATP; OATP1; OATP1A2; SLC21A3; OATP-1
UniProt Entry Name
SO1A2_HUMAN

NCBI Description

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Uniprot Description

SLCO1A2: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids. Selectively inhibited by the grapefruit juice component naringin. Belongs to the organo anion transporter (TC 2.A.60) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: integral to membrane; plasma membrane

Molecular Function: organic anion transmembrane transporter activity

Biological Process: bile acid and bile salt transport; sodium-independent organic anion transport; bile acid metabolic process; transmembrane transport; organic anion transport

Research Articles on OATP1

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Product Notes

The OATP1 slco1a2 (Catalog #AAA3004474) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's OATP1 can be used in a range of immunoassay formats including, but not limited to, Blocking. Researchers should empirically determine the suitability of the OATP1 slco1a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OATP1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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