Ntrk1 blocking peptide

Mouse Ntrk1 Blocking Peptide (Center)

• Gene Names: Ntrk1; Tkr; trk; TrkA; C80751
• Synonyms: Ntrk1; Mouse Ntrk1 Blocking Peptide (Center); High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; Ntrk1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 481-495 of HUMAN Ntrk1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 799

• Cellular Location: Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein Note: Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes (By similarity). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Ntrk1 blocking peptide

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras- PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.

NCBI and Uniprot Product Information

• NCBI GI #: 126253666
• NCBI GeneID: 18211
• UniProt Accession #: Q3UFB7; P35739
• Molecular Weight: 87,738 Da
• NCBI Official Full Name: High affinity nerve growth factor receptor
• NCBI Official Synonym Full Names: neurotrophic tyrosine kinase, receptor, type 1
• NCBI Official Symbol: Ntrk1
• NCBI Official Synonym Symbols: Tkr; trk; TrkA; C80751
• NCBI Protein Information: high affinity nerve growth factor receptor
• UniProt Protein Name: High affinity nerve growth factor receptor
• Protein Family: High affinity nerve growth factor receptor
• UniProt Gene Name: Ntrk1
• UniProt Entry Name: NTRK1_MOUSE

Uniprot Description

TrkA: a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described.

Protein type: Membrane protein, integral; EC 2.7.10.1; Oncoprotein; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; TK group; Trk family

Cellular Component: axon; cell soma; cell surface; cytoplasm; cytoplasmic vesicle; dendrite; early endosome; integral to plasma membrane; late endosome; plasma membrane; protein complex; receptor complex

Molecular Function: GPI-linked ephrin receptor activity; kinase binding; nerve growth factor binding; nerve growth factor receptor activity; neurotrophin p75 receptor binding; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: activation of NF-kappaB transcription factor; axon guidance; B cell differentiation; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; learning and/or memory; mechanoreceptor differentiation; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; nervous system development; positive regulation of angiogenesis; positive regulation of programmed cell death; positive regulation of protein amino acid phosphorylation; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to activity; response to drug; response to electrical stimulus; response to nicotine; response to nutrient levels; sensory perception of pain; Sertoli cell development; sympathetic nervous system development