NR2E1 blocking peptide

NR2E1 Blocking Peptide

Cat. Num. AAA9627404

• Gene Names: NR2E1; TLL; TLX; XTLL
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: NR2E1; NR2E1 Blocking Peptide; hTll; nr2e1; NR2E1_HUMAN; Nuclear receptor subfamily 2 group E member 1; Nuclear receptor TLX; Orphan nuclear receptor NR2E1; Protein tailless homolog; Tailless homolog; Tll; TLX; XTLL; NR2E1 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for NR2E1 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NR2E1 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 554790375
• NCBI GeneID: 7101
• NCBI Accession #: NP_001273031.1
• NCBI GenBank Nucleotide #: NM_001286102.1
• UniProt Accession #: Q9Y466; Q6ZMP8
• Molecular Weight: 42,589 Da
• NCBI Official Full Name: nuclear receptor subfamily 2 group E member 1 isoform a
• NCBI Official Synonym Full Names: nuclear receptor subfamily 2, group E, member 1
• NCBI Official Symbol: NR2E1
• NCBI Official Synonym Symbols: TLL; TLX; XTLL
• NCBI Protein Information: nuclear receptor subfamily 2 group E member 1; tailless homolog; nuclear receptor TLX; tailes-related receptor; protein tailless homolog
• UniProt Protein Name: Nuclear receptor subfamily 2 group E member 1
• Protein Family: Nuclear receptor subfamily
• UniProt Gene Name: NR2E1
• UniProt Synonym Gene Names: TLX; Tll; hTll
• UniProt Entry Name: NR2E1_HUMAN

Uniprot Description

NR2E1: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acic receptor (RAR) regulation in retinal cells. Belongs to the nuclear hormone receptor family. NR2 subfamily.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: nucleoplasm

Molecular Function: zinc ion binding; sequence-specific DNA binding; histone deacetylase binding; steroid hormone receptor activity

Biological Process: extracellular matrix organization and biogenesis; behavioral fear response; somatic stem cell maintenance; regulation of dendrite morphogenesis; regulation of timing of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; amygdala development; cerebral cortex neuron differentiation; visual perception; layer formation in the cerebral cortex; nervous system development; transcription initiation from RNA polymerase II promoter; dentate gyrus development; cell fate commitment; generation of neurons in the forebrain; olfactory bulb development; positive regulation of cell cycle; social behavior; negative regulation of neuron differentiation; positive regulation of angiogenesis; anterior commissure morphogenesis; retina development in camera-type eye; negative regulation of astrocyte differentiation; steroid hormone mediated signaling; gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptosis