NPSR1 blocking peptide

NPSR1 Blocking Peptide

Cat. Num. AAA9623053

• Gene Names: NPSR1; GPRA; NPSR; VRR1; ASRT2; PGR14; GPR154
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: NPSR1; NPSR1 Blocking Peptide; ASRT2; G protein coupled receptor 154; G protein coupled receptor for asthma susceptibility; G protein coupled receptor PGR14; GPR 154; gpr154; GPRA; MVTR; Neuropeptide S receptor 1; Neuropeptide S receptor; nps receptor; NPSR 1; NPSR; PGR 14; PGR14; Vasopressin receptor related receptor 1; VRR 1; VRR1; NPSR1 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for NPSR1 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NPSR1 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 665821295
• NCBI GeneID: 387129
• NCBI Accession #: NP_001287862.1
• NCBI GenBank Nucleotide #: NM_001300933.1
• UniProt Accession #: Q6W5P4; Q2XP58; Q56H76; Q56H77; Q56H78; Q6JSL4; Q6JSL5; Q6JSL6; Q6JSL7; Q6JSL8; Q6W5P3; A2RTZ4
• Molecular Weight: 10,612 Da
• NCBI Official Full Name: neuropeptide S receptor B short
• NCBI Official Synonym Full Names: neuropeptide S receptor 1
• NCBI Official Symbol: NPSR1
• NCBI Official Synonym Symbols: GPRA; NPSR; VRR1; ASRT2; PGR14; GPR154
• NCBI Protein Information: neuropeptide S receptor
• UniProt Protein Name: Neuropeptide S receptor
• Protein Family: Neuropeptide S receptor
• UniProt Gene Name: NPSR1
• UniProt Synonym Gene Names: GPR154; GPRA; PGR14
• UniProt Entry Name: NPSR1_HUMAN

NCBI Description

This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

NPSR1: May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth. Involved in pathogenesis of asthma and other IgE-mediated diseases. Defects in NPSR1 are a cause of asthma-related traits type 2 (ASRT2). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: neuropeptide receptor activity; vasopressin receptor activity

Biological Process: neuropeptide signaling pathway; positive regulation of release of sequestered calcium ion into cytosol

Disease: Asthma-related Traits, Susceptibility To, 2