NCS1 blocking peptide

NCS1 Antibody (Center) Blocking Peptide

• Gene Names: NCS1; FLUP; FREQ
• Synonyms: NCS1; NCS1 Antibody (Center) Blocking Peptide; Neuronal calcium sensor 1; NCS-1; Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein; FLUP; FREQ; NCS1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human NCS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 190

• Cellular Location: Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein Note: Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NCS1 blocking peptide

Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 49065666
• NCBI GeneID: 23413
• UniProt Accession #: P62166; P36610; Q9UK26; E9PAY3
• Molecular Weight: 19,728 Da
• NCBI Official Full Name: Neuronal calcium sensor 1
• NCBI Official Synonym Full Names: neuronal calcium sensor 1
• NCBI Official Symbol: NCS1
• NCBI Official Synonym Symbols: FLUP; FREQ
• NCBI Protein Information: neuronal calcium sensor 1
• UniProt Protein Name: Neuronal calcium sensor 1
• Protein Family: Purine-uracil permease
• UniProt Gene Name: NCS1
• UniProt Synonym Gene Names: FLUP; FREQ; NCS-1
• UniProt Entry Name: NCS1_HUMAN

NCBI Description

This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

FREQ: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel. Interacts with KCND2. Interacts in a calcium-independent manner with PI4KB. This binding competes with CALN2/CABP7 binding to PI4KB. Interacts with ARF1, ARF3, ARF5 and ARF6. Interacts in a calcium-dependent manner with PICK1 (via AH domain). Interacts with IL1RAPL1. Belongs to the recoverin family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: cytoplasm; intracellular membrane-bound organelle; plasma membrane

Molecular Function: calcium ion binding; protein binding; voltage-gated calcium channel activity