MUC4 (Mucin-4 alpha chain) Blocking Peptide | MUC4 blocking peptide

MUC4(Mucin-4 alpha chain) Blocking Peptide (N-term)

• Gene Names: MUC4; ASGP; MUC-4; HSA276359
• Synonyms: MUC4 (Mucin-4 alpha chain); MUC4(Mucin-4 alpha chain) Blocking Peptide (N-term); Mucin-4; MUC-4; Ascites sialoglycoprotein; ASGP; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin; Mucin-4 alpha chain; Ascites sialoglycoprotein 1; ASGP-1; Mucin-4 beta chain; Ascites sialoglycoprotein 2; ASGP-2; MUC4; MUC4 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 529-540 of HUMAN MUC4
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 2169

• Cellular Location: Membrane; Single-pass membrane protein. Secreted Note: Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing Mucin-4 alpha chain: Secreted. Isoform 11: Secreted. Isoform 17: Cell membrane; Single-pass membrane protein
• Tissue Location: Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MUC4 blocking peptide

May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

NCBI and Uniprot Product Information

• NCBI GI #: 338817990
• NCBI GeneID: 4585
• UniProt Accession #: Q99102; O95938; Q9GZM2; Q9GZV6; Q9H481; Q9H482; Q9H483; Q9H484; Q9H485; Q9H486; Q9H487; Q9H4D6
• Molecular Weight: 206,605 Da
• NCBI Official Full Name: Mucin-4
• NCBI Official Synonym Full Names: mucin 4, cell surface associated
• NCBI Official Symbol: MUC4
• NCBI Official Synonym Symbols: ASGP; MUC-4; HSA276359
• NCBI Protein Information: mucin-4
• UniProt Protein Name: Mucin-4
• Protein Family: Mucin
• UniProt Gene Name: MUC4
• UniProt Synonym Gene Names: MUC-4; ASGP; ASGP-1; ASGP-2
• UniProt Entry Name: MUC4_HUMAN

NCBI Description

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]

Uniprot Description

MUC4: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. 14 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: extracellular space; Golgi lumen; integral to plasma membrane; vesicle

Molecular Function: ErbB-2 class receptor binding

Biological Process: maintenance of gastrointestinal epithelium; O-glycan processing