MTIF2 blocking peptide

MTIF2 Antibody (N-term) Blocking Peptide

• Synonyms: MTIF2; MTIF2 Antibody (N-term) Blocking Peptide; Translation initiation factor IF-2; mitochondrial; IF-2(Mt); IF-2Mt; IF2(mt); MTIF2 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 727

• Cellular Location: Mitochondrion.
• Tissue Location: Expressed in all tissues examined. Highest level in skeletal muscle
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MTIF2 blocking peptide

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

NCBI and Uniprot Product Information

• NCBI GI #: 223590069
• NCBI GeneID: 4528
• UniProt Accession #: P46199; D6W5D0
• Molecular Weight: 81,317 Da
• NCBI Official Full Name: Translation initiation factor IF-2, mitochondrial
• NCBI Official Synonym Full Names: mitochondrial translational initiation factor 2
• NCBI Official Symbol: MTIF2
• NCBI Protein Information: translation initiation factor IF-2, mitochondrial
• UniProt Protein Name: Translation initiation factor IF-2, mitochondrial
• UniProt Gene Name: MTIF2
• UniProt Synonym Gene Names: IF-2(Mt); IF-2Mt; IF2(mt)
• UniProt Entry Name: IF2M_HUMAN

NCBI Description

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016]

Uniprot Description

MTIF2: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. Belongs to the IF-2 family.

Protein type: Translation; Translation initiation; Mitochondrial

Chromosomal Location of Human Ortholog: 2p16.1

Cellular Component: mitochondrion; nucleoplasm

Molecular Function: GTPase activity; ribosomal small subunit binding; translation factor activity, nucleic acid binding

Biological Process: regulation of translational initiation; ribosome disassembly