MRP3 blocking peptide

MRP3 (L1010) Peptide

Cat. Num. AAA3003501

• Gene Names: ABCC3; MLP2; MRP3; ABC31; MOAT-D; cMOAT2; EST90757
• Applications: Blocking
• Purity: Synthetic peptide MRP3 (L1010). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: MRP3; MRP3 (L1010) Peptide; ABC 31 antibody ABC31 antibody ABCC 3 antibody ABCC3 antibody ATP binding cassette sub family C (CFTR/MRP) member 3 antibody ATP binding cassette sub family C member 3 antibody ATP-binding cassette sub-family C member 3 antibody Canalicular multispecific organic anion transporter 2 antibody Canicular multispecific organic anion transporter antibody CMOAT 2 antibody CMOAT2 antibody EST90757 antibody MLP 2 antibody MLP2 antibody MOAT D antibody MOAT-D antibody MOATD antibody MRP 3; MRP3 blocking peptide

• Specificity: This peptide can be used with studies using MBS3003500 MRP3 (L1010) pAb.
• Purity/Purification: Synthetic peptide MRP3 (L1010). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 572

• Applicable Applications for MRP3 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for MRP3 blocking peptide

MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps ex- pressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also me- diates the transport of the organic anion S-(2, 4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired.

NCBI and Uniprot Product Information

• NCBI GI #: 221316556
• NCBI GeneID: 8714
• NCBI Accession #: NP_001137542.1
• NCBI GenBank Nucleotide #: NP_001137542.1
• UniProt Accession #: O15438
• NCBI Official Full Name: canalicular multispecific organic anion transporter 2 isoform 2
• NCBI Official Synonym Full Names: ATP binding cassette subfamily C member 3
• NCBI Official Symbol: ABCC3
• NCBI Official Synonym Symbols: MLP2; MRP3; ABC31; MOAT-D; cMOAT2; EST90757
• NCBI Protein Information: canalicular multispecific organic anion transporter 2
• UniProt Protein Name: Canalicular multispecific organic anion transporter 2
• UniProt Gene Name: ABCC3
• UniProt Synonym Gene Names: CMOAT2; MLP2; MRP3; MOAT-D
• UniProt Entry Name: MRP3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

ABCC3: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ABC family; Transporter

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity; ATP binding

Biological Process: bile acid and bile salt transport; bile acid metabolic process; transport; transmembrane transport