MRP-S22 blocking peptide

MRP-S22 (R263) Peptide

Cat. Num. AAA3003638

• Gene Names: MRPS22; GIBT; ODG7; GK002; C3orf5; COXPD5; RPMS22; MRP-S22
• Applications: Blocking
• Purity: Synthetic peptide MRP-S22 (R263). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: MRP-S22; MRP-S22 (R263) Peptide; 28S ribosomal protein S22; mitochondrial; S22mt; MRPS22; C3orf5; RPMS22; ORF Names: GK002; MRP-S22 blocking peptide

• Specificity: This peptide can be used with studies using MBS3003637 MRP-S22 (R263) pAb.
• Purity/Purification: Synthetic peptide MRP-S22 (R263). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 360

• Applicable Applications for MRP-S22 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for MRP-S22 blocking peptide

The mitoribosomes are composed of a 4: 1 ratio of protein to RNA, with the proteins forming two subunits, the 28S subunit and the 39S subunit. Across species, the proteins that make up the mitoribosome subunits vary greatly in sequence, preventing easy recognition by sequence homology. MRP-S22 (mitochondrial 28S ribosomal protein S22), also known as S22mt, is a 360 amino acid mitochondrial ribosomal protein. Localized to the mitochondria, MRP-S22 is present in the 28S subunit of the mitoribosomes. Defects of MRP-S22 are the cause of combined oxidative phosphorylation deficiency type 5 (COXPD5). COXPD5 is an antenatal mitochondrial disease characterized by hypotonia, edema, cardiomyopathy and tubulopathy.

NCBI and Uniprot Product Information

• NCBI GI #: 9910244
• NCBI GeneID: 56945
• NCBI Accession #: NP_064576.1
• NCBI GenBank Nucleotide #: NP_064576.1
• UniProt Accession #: P82650
• NCBI Official Full Name: 28S ribosomal protein S22, mitochondrial isoform 1
• NCBI Official Synonym Full Names: mitochondrial ribosomal protein S22
• NCBI Official Symbol: MRPS22
• NCBI Official Synonym Symbols: GIBT; ODG7; GK002; C3orf5; COXPD5; RPMS22; MRP-S22
• NCBI Protein Information: 28S ribosomal protein S22, mitochondrial
• UniProt Protein Name: 28S ribosomal protein S22, mitochondrial
• UniProt Gene Name: MRPS22
• UniProt Synonym Gene Names: C3orf5; RPMS22; MRP-S22; S22mt
• UniProt Entry Name: RT22_HUMAN

NCBI Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq. [provided by RefSeq, Jul 2008]

Uniprot Description

MRPS22: Defects in MRPS22 are the cause of combined oxidative phosphorylation deficiency type 5 (COXPD5). COXPD5 is an antenatal mitochondrial disease. Patients show edema, cardiomyopathy, tubulopathy, and hypotonia.

Protein type: Mitochondrial; Translation; Ribosomal

Chromosomal Location of Human Ortholog: 3q23

Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial small ribosomal subunit; mitochondrial ribosome

Molecular Function: structural constituent of ribosome

Biological Process: mitochondrial translation; organelle organization and biogenesis

Disease: Combined Oxidative Phosphorylation Deficiency 5