MRI1 blocking peptide

MRI1 Blocking Peptide (Center)

Gene Names

MRI1; M1Pi; MRDI; MTNA; Ypr118w

Synonyms

MRI1; MRI1 Blocking Peptide (Center); Methylthioribose-1-phosphate isomerase ; M1Pi ; MTR-1-P isomerase ; 5.3.1.23 ; Mediator of RhoA-dependent invasion; S-methyl-5-thioribose-1-phosphate isomerase ; Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein ; MRI1 ; MRDI; MRI1 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 128-141 of HUMAN MRI1

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

369

Cellular Location

Nucleus. Cytoplasm. Cell projection. Note: Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MRI1 blocking peptide

Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.

NCBI and Uniprot Product Information

NCBI GI #

74733279

NCBI GeneID

84245

UniProt Accession #

Q9BV20; Q8NDC9

Molecular Weight

34,529 Da

NCBI Official Full Name

Methylthioribose-1-phosphate isomerase

NCBI Official Synonym Full Names

methylthioribose-1-phosphate isomerase 1

NCBI Official Symbol

MRI1

NCBI Official Synonym Symbols

M1Pi; MRDI; MTNA; Ypr118w

NCBI Protein Information

methylthioribose-1-phosphate isomerase

UniProt Protein Name

Methylthioribose-1-phosphate isomerase

Protein Family

Methylthioribose-1-phosphate isomerase

UniProt Gene Name

MRI1

UniProt Synonym Gene Names

M1Pi; MTR-1-P isomerase

UniProt Entry Name

MTNA_HUMAN

NCBI Description

This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]

Uniprot Description

MRI1: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Isomerase; EC 5.3.1.23

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytoplasm; cytosol; nucleolus

Molecular Function: identical protein binding; S-methyl-5-thioribose-1-phosphate isomerase activity

Biological Process: methionine salvage

Research Articles on MRI1

1. Data indicate that the structural elements in MRDI distal from the MTR-1-P catalytic site are responsible for the invasion phenotype.

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Product Notes

The MRI1 mri1 (Catalog #AAA9230626) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MRI1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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MRI1 blocking peptide