MOK blocking peptide

Phospho-MOK (Tyr161) Blocking Peptide

Cat. Num. AAA9619134

• Gene Names: MOK; RAGE; RAGE1; RAGE-1
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: MOK; Phospho-MOK (Tyr161) Blocking Peptide; Antigen recognized by autologous cytolytic T lymphocytes; EC 2.7.11.22; LE 9211 A antigen; MAPK/MAK/MRK overlapping kinase; MOK protein kinase; MOK_HUMAN; RAGE 1; RAGE; RAGE-1; RAGE1; Renal cell carcinoma antigen (MOK protein kinase); Renal tumor antigen 1; Renal tumor antigen; STK30; MOK blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for MOK blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MOK blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 436408722
• NCBI GeneID: 5891
• NCBI Accession #: NP_001258940.1
• NCBI GenBank Nucleotide #: NM_001272011.1
• UniProt Accession #: Q9UQ07; Q92790; Q93067
• Molecular Weight: 48,014 Da
• NCBI Official Full Name: MAPK/MAK/MRK overlapping kinase isoform 2
• NCBI Official Synonym Full Names: MOK protein kinase
• NCBI Official Symbol: MOK
• NCBI Official Synonym Symbols: RAGE; RAGE1; RAGE-1
• NCBI Protein Information: MAPK/MAK/MRK overlapping kinase; renal tumor antigen 1; renal cell carcinoma antigen
• UniProt Protein Name: MAPK/MAK/MRK overlapping kinase
• Protein Family: MAPK/MAK/MRK overlapping kinase
• UniProt Gene Name: MOK
• UniProt Synonym Gene Names: RAGE; RAGE1; RAGE-1
• UniProt Entry Name: MOK_HUMAN

NCBI Description

This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

Uniprot Description

MOK: a CMGC protein kinase of the RCK family. Possesses a Thr-Glu-Tyr motif in the activation loop domain, as do classical MAP kinases. Associates with and is apparently stabilized by HSP90.

Protein type: EC 2.7.11.22; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CMGC group; RCK family

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: cytoplasm

Molecular Function: protein serine/threonine kinase activity; cyclin-dependent protein kinase activity; ATP binding; protein kinase activity

Biological Process: regulation of cell cycle; signal transduction; protein amino acid phosphorylation