MMP19 blocking peptide

MMP19 Antibody (N-term) Blocking peptide

• Gene Names: MMP19; CODA; MMP18; RASI-1
• Synonyms: MMP19; MMP19 Antibody (N-term) Blocking peptide; Matrix metalloproteinase-19; MMP-19; 3424-; Matrix metalloproteinase RASI; Matrix metalloproteinase-18; MMP-18; MMP18; RASI; MMP19 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of MMP19. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 508

• Cellular Location: Secreted, extracellular space, extracellular matrix
• Tissue Location: Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MMP19 blocking peptide

Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.

NCBI and Uniprot Product Information

• NCBI GI #: 12643345
• NCBI GeneID: 4327
• UniProt Accession #: Q99542; O15278; O95606; Q99580; B4E030
• Molecular Weight: 33,793 Da
• NCBI Official Full Name: Matrix metalloproteinase-19
• NCBI Official Synonym Full Names: matrix metallopeptidase 19
• NCBI Official Symbol: MMP19
• NCBI Official Synonym Symbols: CODA; MMP18; RASI-1
• NCBI Protein Information: matrix metalloproteinase-19
• UniProt Protein Name: Matrix metalloproteinase-19
• Protein Family: Matrix metalloproteinase
• UniProt Gene Name: MMP19
• UniProt Synonym Gene Names: MMP18; RASI; MMP-19; MMP-18
• UniProt Entry Name: MMP19_HUMAN

NCBI Description

This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

Uniprot Description

MMP19: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients. Belongs to the peptidase M10A family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Protease; Secreted, signal peptide; EC 3.4.24.-

Chromosomal Location of Human Ortholog: 12q14

Cellular Component: extracellular region

Molecular Function: serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly

Disease: Cavitary Optic Disc Anomalies