MBOAT7 blocking peptide

MBOAT7 Blocking Peptide(Center)

• Gene Names: MBOAT7; BB1; LRC4; LENG4; LPIAT; MBOA7; OACT7; hMBOA-7
• Synonyms: MBOAT7; MBOAT7 Blocking Peptide(Center); Lysophospholipid acyltransferase 7; LPLAT 7; 231-; 1-acylglycerophosphatidylinositol O-acyltransferase; 231n4; Bladder and breast carcinoma-overexpressed gene 1 protein; Leukocyte receptor cluster member 4; Lysophosphatidylinositol acyltransferase; LPIAT; Lyso-PI acyltransferase; Membrane-bound O-acyltransferase domain-containing protein 7; O-acyltransferase domain-containing protein 7; h-mboa-7; BB1; LENG4; OACT7; MBOAT7 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 166-180 of HUMAN MBOAT7
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 399

• Cellular Location: Membrane; Multi-pass membrane protein
• Tissue Location: Overexpressed in metastatic breast and bladder carcinomas relative to normal breast epithelium and urothelium
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MBOAT7 blocking peptide

Acyltransferase which mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3- phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

NCBI and Uniprot Product Information

• NCBI GI #: 225703081
• NCBI GeneID: 79143
• NCBI Accession #: NP_001139528.1
• NCBI GenBank Nucleotide #: NM_001146056.2
• UniProt Accession #: Q96N66; Q05DF0; Q7L5N2; Q99908; Q9BPV2; Q9BRE9; A9C4B6; B0V3I5; B4DQ87
• Molecular Weight: 38,470 Da
• NCBI Official Full Name: lysophospholipid acyltransferase 7 isoform 2
• NCBI Official Synonym Full Names: membrane bound O-acyltransferase domain containing 7
• NCBI Official Symbol: MBOAT7
• NCBI Official Synonym Symbols: BB1; LRC4; LENG4; LPIAT; MBOA7; OACT7; hMBOA-7
• NCBI Protein Information: lysophospholipid acyltransferase 7
• UniProt Protein Name: Lysophospholipid acyltransferase 7
• Protein Family: Lysophospholipid acyltransferase
• UniProt Gene Name: MBOAT7
• UniProt Synonym Gene Names: BB1; LENG4; OACT7; LPLAT 7; LPIAT; Lyso-PI acyltransferase; O-acyltransferase domain-containing protein 7; h-mboa-7
• UniProt Entry Name: MBOA7_HUMAN

NCBI Description

This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Uniprot Description

LENG4: Acyltransferase which mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3- phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Belongs to the membrane-bound acyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.3.1.n4; Transferase; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: endoplasmic reticulum membrane; membrane

Molecular Function: 1-acylglycerol-3-phosphate O-acyltransferase activity; 2-acylglycerol-3-phosphate O-acyltransferase activity; protein binding