MAD1L1 blocking peptide

MAD1L1 Antibody (N-term) Blocking peptide

• Gene Names: MAD1L1; MAD1; PIG9; TP53I9; TXBP181
• Synonyms: MAD1L1; MAD1L1 Antibody (N-term) Blocking peptide; Mitotic spindle assembly checkpoint protein MAD1; Mitotic arrest deficient 1-like protein 1; MAD1-like protein 1; Mitotic checkpoint MAD1 protein homolog; HsMAD1; hMAD1; Tax-binding protein 181; MAD1; TXBP181; MAD1L1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 718

• Cellular Location: Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note: From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Colocalizes with NEK2 at the kinetochore
• Tissue Location: Expressed weakly at G0/G1 and highly at late S and G2/M phase
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MAD1L1 blocking peptide

Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.

NCBI and Uniprot Product Information

• NCBI GI #: 52783153
• NCBI GeneID: 8379
• UniProt Accession #: Q9Y6D9; Q13312; Q75MI0; Q86UM4; Q9UNH0; B3KR41
• Molecular Weight: 72,286 Da
• NCBI Official Full Name: Mitotic spindle assembly checkpoint protein MAD1
• NCBI Official Synonym Full Names: MAD1 mitotic arrest deficient like 1
• NCBI Official Symbol: MAD1L1
• NCBI Official Synonym Symbols: MAD1; PIG9; TP53I9; TXBP181
• NCBI Protein Information: mitotic spindle assembly checkpoint protein MAD1
• UniProt Protein Name: Mitotic spindle assembly checkpoint protein MAD1
• Protein Family: Mitotic spindle assembly checkpoint protein
• UniProt Gene Name: MAD1L1
• UniProt Synonym Gene Names: MAD1; TXBP181; MAD1-like protein 1; HsMAD1; hMAD1
• UniProt Entry Name: MD1L1_HUMAN

NCBI Description

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Uniprot Description

MAD1L1: a component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Expressed weakly at G0/G1 and highly at late S and G2/M phase. Induced by p53. Becomes hyperphosphorylated in late S through M phases or after mitotic spindle damage. Two alternatively spliced isoforms have been described. Defects in MAD1L1 are involved in the development and/or progression of various types of cancer.

Protein type: Cell cycle regulation; Cytoskeletal

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: actin cytoskeleton; cytoplasm; cytosol; kinetochore; nuclear pore; nucleus

Molecular Function: protein binding

Biological Process: sister chromatid cohesion

Disease: Prostate Cancer